DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and ARFGAP3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_055385.3	Gene:	ARFGAP3 / 26286	HGNCID:	661	Length:	516	Species:	Homo sapiens

Alignment Length:	312	Identity:	80/312 - (25%)
Similarity:	124/312 - (39%)	Gaps:	70/312 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 PAKRRI--HWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLD 439
            |:|:.|  .::....:|.|..|.||.:..|.||||..|:.|||:|||.|||||||.|.:||..||
Human     4 PSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELD 68

  Fly   440 A-WESENVKVMMELGNEVVNRIYEAR--IGDDCGLKKPTEQCEIGVRE----------------A 485
            : |....::.|...||...:..:...  ..:|...|..:...:: .||                .
Human    69 SNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQL-YREKIKSLASQATRKHGTDL 132

  Fly   486 WIKAKYV--------ERRFVCGMPKPQ---ELLASETAEVLSIDSGGV---VEDGESG------- 529
            |:.:..|        |..|......|:   ...||..||..|:.|..|   :|:.|.|
Human   133 WLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSV 197

  Fly   530 -GSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNT--------AKTGDELEDDD 585
             |..:..:|||.:....|   ||..:.:|.....|.......:.||        |:..|::::.:
Human   198 EGLNVPTKATLEVSSIIK---KKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQE 259

  Fly   586 D-------DESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTD 630
            |       :|||   ..||.::..||     ::.:.:.|...|.|.....:|
Human   260 DLAKVVSKEESI---VSSLRLAYKDL-----EIQMKKDEKMNISGKKNVDSD 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	40/139 (29%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
ARFGAP3	NP_055385.3	PLN03114	1..464	CDD:178661	80/312 (26%)
		ArfGap	12..116	CDD:279720	36/104 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..199		8/28 (29%)
		TMF_DNA_bd	246..301	CDD:289127	13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..346
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900