DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and cnt6

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_594153.1	Gene:	cnt6 / 2542074	PomBaseID:	SPAC26A3.10	Length:	923	Species:	Schizosaccharomyces pombe

Alignment Length:	695	Identity:	145/695 - (20%)
Similarity:	249/695 - (35%)	Gaps:	221/695 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQR-----------LEKIIKLCNVAVDSGKEYV---- 53
            |:.|.|..:|.|.||       |.:..|||:           :::|::|.: |.|:.:..|
pombe   221 TVIFPENYEDGPSFR-------SMLHELEQKSSLMKYYCKKIMKRIVQLSD-AYDASQVAVMKLS 277

  Fly    54 ------KNQSAFAMSL---------WDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASR 103
                  .|.::..|.:         .|:...|:...|.     .||:...|  .||.|
pombe   278 ETLSEASNSTSMNMDILLDSYLTKAMDIHATFIQKLNY-----DLINLLYE--PFHNI------- 328

  Fly   104 TVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQH 168
                 .|.|:|    .:.|.:..|.:.|:.:..:|.:...|.|::.          ......||.
pombe   329 -----YSSFIK----PIDDRRLEFDEQSKSFYGSLSRYLSAKKDKK----------GGDSKFFQK 374

  Fly   169 T---ALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNAL--- 227
            .   ||...:|....|.....||::.:...:   :.|:|:.:|....|.....::..:|..|
pombe   375 EKTFALQRYDYYCFMQDLHDGSIINDINGIF---LQYFHRQYDHIALFSNLMNSVLPNLQQLNLK 436

  Fly   228 ---------RGD---------------------------------YQQLEKAMQNRHMSVNRYCD 250
                     |.|                                 ..:::..|.||.|:.:....
pombe   437 LEKTKWSTTRRDKGREMHRSQVIQTSGRPKSMAPPSPSPISPSFPLHEIQSPMPNRRMAASADDI 501

  Fly   251 SNTNSTSNKIEGYLFK-----KKSKGFK----------------------TWCRRWFYLSDNQL- 287
            |.|::.:.:|:|....     ...|.||                      .|.:.|..:.:..|
pombe   502 SQTSNFTTEIKGKCISNGGSASPDKIFKEGLLLVFGATELGTDLAMVSKAAWHKHWIVVENGSLW 566

  Fly   288 VYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHS- 351
            .|....:....:|....|:..|...|.:..|||||||::|....:.||.||:.:..||.|:..:
pombe   567 EYANWKDSVKSNVSSISLKHASADKVRKQGRRFCFEVVTPKLKRLYQATSAEEMDSWIEAICEAA 631

  Fly   352 -------------IGAAIQH------------DSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIP 391
                         :.|:::.            ::|..||..|.:....:...|...:.::|.:..
pombe   632 KISSFQLSRVATPLSASVRRPSKVFPLFSTSFETTPISRKLSGSGIKKAFSRKGSWNLQQFFRSD 696

  Fly   392 -----------------------------GNAYCCDCRS-PEPRWASINLGITLCIECSGVHRSL 426
                                         .|:.|.||.| .:..|.|||:.:.|||||||:||||
pombe   697 NSGTMHMEQLERYHASANIFIQMLRKTDVSNSVCADCGSVKDVTWCSINIPVVLCIECSGIHRSL 761

  Fly   427 GVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKY 491
            |.|.||.|||.||:...::..::.::||..|||:||..:.:.....||....:  |:.|:.:.||
pombe   762 GTHISKTRSLLLDSLSQQSKVLLCKIGNAAVNRVYEKGLSNPSLKPKPEHNAQ--VKLAFAQKKY 824

  Fly   492 VERRFV--CGMPKPQELL----ASETAEVL-------SIDSGGVV 523
            ||..|:  .|:.....||    .::.:::|       :.:..|||
pombe   825 VEHAFIDFAGVDADATLLEGLEQNKISKILLGLAAKPNFEENGVV 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	42/231 (18%)
		PH	259..352	CDD:278594	28/134 (21%)
		PH_ACAP	260..355	CDD:270070	28/136 (21%)
		ArfGap	384..497	CDD:279720	45/142 (32%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
cnt6	NP_594153.1	BAR_ArfGAP_fungi	236..430	CDD:153292	41/230 (18%)
		PH	527..632	CDD:214574	25/104 (24%)
		PH	550..632	CDD:278594	23/81 (28%)
		ArfGap	717..837	CDD:214518	46/121 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2027
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I1446
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		mtm9294
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
TreeFam	0	0.000	Not matched by this tool.
	11	10.890