Protein Alignment CenB1A and cnt6

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_594153.1
• Gene: cnt6 / 2542074
• PomBaseID: SPAC26A3.10
• Length: 923
• Species: Schizosaccharomyces pombe
• Alignment Length: 695
• Identity: 145/695 - (20%)
• Similarity: 249/695 - (35%)
• Gaps: 221/695 - (31%)

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQR-----------LEKIIKLCNVAVDSGKEYV---- 53
            |:.|.|..:|.|.||       |.:..|||:           :::|::|.: |.|:.:..|
pombe   221 TVIFPENYEDGPSFR-------SMLHELEQKSSLMKYYCKKIMKRIVQLSD-AYDASQVAVMKLS 277

  Fly    54 ------KNQSAFAMSL---------WDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASR 103
                  .|.::..|.:         .|:...|:...|.     .||:...|  .||.|
pombe   278 ETLSEASNSTSMNMDILLDSYLTKAMDIHATFIQKLNY-----DLINLLYE--PFHNI------- 328

  Fly   104 TVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQH 168
                 .|.|:|    .:.|.:..|.:.|:.:..:|.:...|.|::.          ......||.
pombe   329 -----YSSFIK----PIDDRRLEFDEQSKSFYGSLSRYLSAKKDKK----------GGDSKFFQK 374

  Fly   169 T---ALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNAL--- 227
            .   ||...:|....|.....||::.:...:   :.|:|:.:|....|.....::..:|..|
pombe   375 EKTFALQRYDYYCFMQDLHDGSIINDINGIF---LQYFHRQYDHIALFSNLMNSVLPNLQQLNLK 436

  Fly   228 ---------RGD---------------------------------YQQLEKAMQNRHMSVNRYCD 250
                     |.|                                 ..:::..|.||.|:.:....
pombe   437 LEKTKWSTTRRDKGREMHRSQVIQTSGRPKSMAPPSPSPISPSFPLHEIQSPMPNRRMAASADDI 501

  Fly   251 SNTNSTSNKIEGYLFK-----KKSKGFK----------------------TWCRRWFYLSDNQL- 287
            |.|::.:.:|:|....     ...|.||                      .|.:.|..:.:..|
pombe   502 SQTSNFTTEIKGKCISNGGSASPDKIFKEGLLLVFGATELGTDLAMVSKAAWHKHWIVVENGSLW 566

  Fly   288 VYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHS- 351
            .|....:....:|....|:..|...|.:..|||||||::|....:.||.||:.:..||.|:..:
pombe   567 EYANWKDSVKSNVSSISLKHASADKVRKQGRRFCFEVVTPKLKRLYQATSAEEMDSWIEAICEAA 631

  Fly   352 -------------IGAAIQH------------DSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIP 391
                         :.|:::.            ::|..||..|.:....:...|...:.::|.:..
pombe   632 KISSFQLSRVATPLSASVRRPSKVFPLFSTSFETTPISRKLSGSGIKKAFSRKGSWNLQQFFRSD 696

  Fly   392 -----------------------------GNAYCCDCRS-PEPRWASINLGITLCIECSGVHRSL 426
                                         .|:.|.||.| .:..|.|||:.:.|||||||:||||
pombe   697 NSGTMHMEQLERYHASANIFIQMLRKTDVSNSVCADCGSVKDVTWCSINIPVVLCIECSGIHRSL 761

  Fly   427 GVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKY 491
            |.|.||.|||.||:...::..::.::||..|||:||..:.:.....||....:  |:.|:.:.||
pombe   762 GTHISKTRSLLLDSLSQQSKVLLCKIGNAAVNRVYEKGLSNPSLKPKPEHNAQ--VKLAFAQKKY 824

  Fly   492 VERRFV--CGMPKPQELL----ASETAEVL-------SIDSGGVV 523
            ||..|:  .|:.....||    .::.:::|       :.:..|||
pombe   825 VEHAFIDFAGVDADATLLEGLEQNKISKILLGLAAKPNFEENGVV 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	42/231 (18%)
		PH_ACAP	260..355	CDD:270070	28/136 (21%)
		ArfGap_ACAP	381..497	CDD:350064	45/145 (31%)
		ANKYR	<647..>768	CDD:440430
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
cnt6	NP_594153.1	BAR_ArfGAP_fungi	236..430	CDD:153292	41/230 (18%)
		PH	527..632	CDD:214574	25/104 (24%)
		COG5347	714..>923	CDD:227651	52/158 (33%)