Protein Alignment CenB1A and cnt5

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: NP_595897.1
• Gene: cnt5 / 2539865
• PomBaseID: SPBC17G9.08C
• Length: 870
• Species: Schizosaccharomyces pombe
• Alignment Length: 798
• Identity: 178/798 - (22%)
• Similarity: 279/798 - (34%)
• Gaps: 280/798 - (35%)

  Fly    12 KDSPRFRQFVSKEESDIEHLEQRLEKIIK-LCNVAVDSGKEYVK--------------NQSAFAM 61
            :|.|.||..:...|.....:...|:|:|| :.:||...|..|:.              |..||
pombe   250 EDGPLFRATILNYERTTHDMRMVLKKLIKRIEHVAHSHGLLYMSYKELMSAFERVATINPPAF-- 312

  Fly    62 SLWDLQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKN-----LSVFVKDDINQVK 121
                  :.|||:..|..|        |..:.|:   :|:|  .:|:|     |......||..|.
pombe   313 ------KPFLDHYYAAAA--------QSFDSFN---IDRA--RLLRNFLIEPLRKIYDTDIKNVS 358

  Fly   122 DYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYI-TLAQARKV 185
            ..|..|.:.|..|..:|.:....|:......:...:..:|.|..|:.:..||.:|: .:...||.
pombe   359 TKKKDFEETSRDYYTSLSRYLSKSEKETSSDKTKESKFAAKKRDFELSRFDYYSYMQDINGGRKG 423

  Fly   186 PSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAM--QNRHMSV--- 245
            ..:||.|..:             ..||::....::: |::|||....||:..:  .|:...:
pombe   424 QEVLSVLTSF-------------AANDYNLIHSSLT-DIDALRPSIIQLQDIVTEANKEFQLLRA 474

  Fly   246 -----NRYCDSNTNSTSNK---IEGYLFKKK---------------SK--------GFKTWCRRW 279
                 .||.::::....:|   |....:|.|               ||        |...|.:.|
pombe   475 EREERRRYIETSSRELEDKDAEIAAQAYKAKVDQDTSAKQGLLLAFSKSTSDLQVVGKSGWHKYW 539

  Fly   280 FYLSDNQLVYRKRSNEDSFSVMEE--DLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLS 342
            ..| |:..:....:.:.|..:..|  ||.:.:|||.....|:||||||:|......||.|...:.
pombe   540 VVL-DHGKICEYANWKQSLELHTEPIDLLMATVRPAQSVSRKFCFEVITPQTKRTYQATSKAEMH 603

  Fly   343 LWISALQHSIGAAI-----------QHDSTHH----------SRPQSTNAP---NNSLPAKRRIH 383
            .||.|:|:||..:|           :..|..|          .|..|..:|   |:....|::..
pombe   604 SWIEAIQYSISESIVQKGKGTSMNSEETSVKHGPTSTIGKALQRVASVTSPSRHNSDSKEKKQTK 668

  Fly   384 WEEFLKI-----PGNAYCCDCR-SPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWE 442
            ....:|.     ..:..|.||. :....|.:||..:.|||:|||:|||||.|.:|:||||||.:.
pombe   669 SPSLVKTLKEMHSSDQSCADCNTTARVEWCAINFPVVLCIDCSGIHRSLGTHITKIRSLTLDKFN 733

  Fly   443 SENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELL 507
            .|.|.::...||..||.|||..| .|..:|....|..   |..::|.||:.:||
pombe   734 PETVDLLYATGNSFVNEIYEGGI-TDWKIKNFENQER---RVQFVKDKYLYKRF----------- 783

  Fly   508 ASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIY 572
                                                                 |..:.|.||
pombe   784 -----------------------------------------------------IKSSFSHDP--- 792

  Fly   573 NTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAES 637
            ||                                             |:|.|.:.|...|:
pombe   793 NT---------------------------------------------GLLESIEHSNLKEA---- 808

  Fly   638 PEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFL 702
                                     |:|:  |||||..:      ||:.: :|::..:.:..|.|
pombe   809 -------------------------VLCL--ALGADVNY------QRAVV-KALLKNNYLIAELL 839

  Fly   703 LLNGAAIDAVDEMGYSAL 720
            .||||::: |||:....|
pombe   840 TLNGASLN-VDEVTMETL 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	47/219 (21%)
		PH_ACAP	260..355	CDD:270070	34/119 (29%)
		ArfGap_ACAP	381..497	CDD:350064	44/121 (36%)
		ANKYR	<647..>768	CDD:440430	20/74 (27%)
		ANK repeat	687..713	CDD:293786	7/25 (28%)
		ANK repeat	715..746	CDD:293786	1/6 (17%)
cnt5	NP_595897.1	BAR_ArfGAP_fungi	257..455	CDD:153292	50/232 (22%)
		PH-like	513..614	CDD:473070	30/101 (30%)
		COG5347	671..>870	CDD:227651	76/341 (22%)
		ANK repeat	791..821	CDD:293786	16/114 (14%)
		ANK repeat	822..847	CDD:293786	8/25 (32%)