DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and ACAP2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_016861535.1	Gene:	ACAP2 / 23527	HGNCID:	16469	Length:	848	Species:	Homo sapiens

Alignment Length:	894	Identity:	335/894 - (37%)
Similarity:	488/894 - (54%)	Gaps:	129/894 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |:.|::||||||||||||..:.:.|.|:..||.:|:|::|||...:|:||.:......|...:.|
Human     1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRD 65

  Fly    66 LQQHFLDNKNAHNALGKLIHCFQEMNKFHT----------------------------ILLDQAS 102
            |.|:..::.....:|.|.....|||..|||                            ||.||..
Human    66 LAQYSSNDAVVETSLTKFSDSLQEMINFHTRQGLPLSLRLECRGMIIALLWESSHLRMILFDQTQ 130

  Fly   103 RTVLKNLSVFVKDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQ 167
            |::...|..|||:|:.:.||.|..|.||||..:|||:||||..:|:..|::||.|||:|::.||:
Human   131 RSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFR 195

  Fly   168 HTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQ 232
            |.|||||..|.:.|:::...||.::|.:..|.:.::|||:||.::...:.|::...|:.|..|..
Human   196 HIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAA 260

  Fly   233 QLEKAMQNRHMSVNRYCDSNTNS-------TSNKI--EGYLFKKKSKGFKTW-------CRRWFY 281
            :.::.|:.:|.::.:...|:.:|       .:|.|  ||||||:.|..||||       .||||.
Human   261 KEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRKKPDHIRRWFS 325

  Fly   282 LSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWIS 346
            :.:|||||:|:. :|:.:|:.||||:|:|:...:.:|||||||:|||||.:|||||..:...||.
Human   326 IQNNQLVYQKKF-KDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIK 389

  Fly   347 ALQHSIGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLK----------IPGNAYCCDCRS 401
            |:|.||..|.:.......:....::|:...........|:.||          |||||.||||..
Human   390 AVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGL 454

  Fly   402 PEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIG 466
            .:||||||||||||||||||:|||||||:|||||||||.||.|.:|:|.||||:|:||:|||.:
Human   455 ADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANV- 518

  Fly   467 DDCGLKKPTEQCEIGVR---EAWIKAKYVERRFV------CGMPKPQELLASETAEV--LSIDSG 520
            :..|:|||    :.|.|   ||:|:||||||:||      ...|:.|:...|:::|.  |||...
Human   519 EKMGIKKP----QPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKF 579

  Fly   521 GVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTA------KTGD 579
            |       .|..:...|..|:     .||.....|::....|..|....|.::|:      ::.|
Human   580 G-------PGDQVRASAQSSV-----IAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIRSND 632

  Fly   580 E-LEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPF 643
            . ::...||...::||   ::|.:.|.                          |.:.|..:...|
Human   633 SGIQQSSDDGRESLPS---TVSANSLY--------------------------EPEGERQDSSMF 668

  Fly   644 SQLDANQL-----LYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLL 703
              ||:..|     ||.||...|||.|..|.|.|||..|.|.::.:.:.|.|||:.||::.|||||
Human   669 --LDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLL 731

  Fly   704 LNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLL 768
            .|||.::..|..|...||.:|..||..||.|.||..|....:..:||..|.|||:..||||||||
Human   732 QNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLL 796

  Fly   769 RLTQLNDEIGPNDEYNGE--DETYKNVMKDFSKLPASQTRVL-RQRHDS 814
            ||.::|:|:..::...|:  ||||:::.:|||::.::....| |.:.||
Human   797 RLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDS 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	77/226 (34%)
		PH	259..352	CDD:278594	51/101 (50%)
		PH_ACAP	260..355	CDD:270070	53/103 (51%)
		ArfGap	384..497	CDD:279720	76/125 (61%)
		ANK	652..768	CDD:238125	54/115 (47%)
		Ank_4	683..736	CDD:290365	24/52 (46%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
ACAP2	XP_016861535.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3294
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8182
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm40931
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870