DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Adap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_766311.2	Gene:	Adap1 / 231821	MGIID:	2442201	Length:	374	Species:	Mus musculus

Alignment Length:	381	Identity:	95/381 - (24%)
Similarity:	158/381 - (41%)	Gaps:	90/381 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 LPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDA 440
            :..:||....|.|..|||..|.||.:|:|.|||..||:.:|:.|||:||:: ...|||:|:.|||
Mouse     1 MAGERRRALLELLTRPGNTRCADCGAPDPDWASYTLGVFICLSCSGIHRNI-PQVSKVKSVRLDA 64

  Fly   441 WESENVKVMMELGNEVVNRIYEARIGDDCGLKKPT-EQCEIGVREAWIKAKYVERRFVCGMPKPQ 504
            |:...|:.|...|||.....:|:::..  ...:|| ..|:: :||.||:|||..:.||  ..:.|
Mouse    65 WDEAQVEFMASHGNEAARATFESKVPP--FYYRPTFSDCQL-LREQWIRAKYERQEFV--HVEKQ 124

  Fly   505 ELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDP 569
            |..::...|      |.:.:.|...|..::::..|:   .|:.|:|...:...:.  ||.:....
Mouse   125 EPYSTGYRE------GLLWKRGRDNGQFLSRKFVLT---EREGALKYFNKNDAKE--PKAVMKIE 178

  Fly   570 SI---YNTAKTGDE-------LEDD---------DDDESINIPSMSLSISRDDLLVIGDDLALDR 615
            .:   :..||.|..       |:|:         :|.:.|.....:|..:|...|.:....|.|.
Mouse   179 HLNATFQPAKMGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDA 243

  Fly   616 LETPGILGSDQESTDGESDAESPEELP-----FSQLDANQLLYMASVVHNLPVMCMAFALGADKM 675
            ...|.:  |.....:|..:...|::..     :..:|..:|:|
Mouse   244 DLVPKL--SRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMY---------------------- 284

  Fly   676 WKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALH---ISTAKGH 728
            :|:|.|   :|....|..||                 .|.||:.|.   :|| :||
Mouse   285 FKDPLD---AFARGEVFIGS-----------------KESGYTVLEGLPLST-QGH 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	45/113 (40%)
		ANK	652..768	CDD:238125	16/80 (20%)
		Ank_4	683..736	CDD:290365	12/49 (24%)
		ANK repeat	687..713	CDD:293786	3/25 (12%)
		ANK repeat	715..746	CDD:293786	7/17 (41%)
Adap1	NP_766311.2	ArfGap	10..126	CDD:214518	48/121 (40%)
		PH1_ADAP	130..238	CDD:270072	20/118 (17%)
		PH2_ADAP	252..357	CDD:241282	20/111 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810