DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Agfg2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001290195.1	Gene:	Agfg2 / 231801	MGIID:	2443267	Length:	490	Species:	Mus musculus

Alignment Length:	292	Identity:	64/292 - (21%)
Similarity:	105/292 - (35%)	Gaps:	74/292 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 GNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEV 456
            ||.:|.:|......:..|.:|..:|..|||:.|.|...: :|:|:::..:....|..:...||||
Mouse    43 GNRHCFECAQRGVTYVDITVGSFVCTTCSGLLRGLNPPH-RVKSISMTTFTEPEVLFLQSRGNEV 106

  Fly   457 VNRI----YEAR---IGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEV 514
            ..:|    ::||   |.|....:|..|         :::.||.::|:.  :|..|
Mouse   107 CRKIWLGLFDARTSLIPDSRDPQKVKE---------FLQEKYEKKRWY--VPPEQ---------- 150

  Fly   515 LSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIP-----KTLSDD--PSIY 572
                               .|..:.|.|......|        |.|:|     :||..|  ||:.
Mouse   151 -------------------VKGPSYSKGSVSATPV--------QGSVPEGKPIRTLLGDPVPSLS 188

  Fly   573 NTAKTG------DELEDDDDDESINIPS-MSLSISRDDLLVIGDDLALDRLETPGILGSDQESTD 630
            :.|.|.      .:........|...|| .|...:..|||.   |:..|....|.::.: ..|..
Mouse   189 DPASTSSQPGSQSQARSSSQARSSQPPSHSSTKKASTDLLA---DIGGDPFAAPQVVPA-FASFP 249

  Fly   631 GESDAESPEELPFSQLDANQLLYMASVVHNLP 662
            |....::|....|:..||......:|...:||
Mouse   250 GFGVGQTPAHGGFANFDAFSSSPSSSTFGSLP 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	29/111 (26%)
		ANK	652..768	CDD:238125	3/11 (27%)
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
Agfg2	NP_001290195.1	ArfGap	40..152	CDD:295313	31/149 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900