DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and cnt-1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001369802.1	Gene:	cnt-1 / 174848	WormBaseID:	WBGene00000565	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	892	Identity:	274/892 - (30%)
Similarity:	413/892 - (46%)	Gaps:	163/892 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDL-QQ 68
            |:..|.::|||:||..|::.......||.||.::::.....:|..|.|........:|:..| .:
Worm    17 IDCSEAIQDSPKFRATVAQHAMYFNRLENRLNEMLRHITAMIDFSKNYTNTFYKLTVSVNQLCDE 81

  Fly    69 HFLDNKNAHNALGKLIHCF-QEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSE 132
            .|..|..|......|...: ..:|.|.| ..|.::......||.|:|.::.:|.:.:.||..:|:
Worm    82 SFSGNPLASTTFQGLSEAYAHTVNLFRT-YFDHSNVVTFTKLSNFIKIELTKVAESRAHFENMSQ 145

  Fly   133 GYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQ 197
            ..|:||:|||..|:.:|.:..|..|.|:|..:||.||.||||..|.:|.|.|...||..|....:
Worm   146 SMDDALVKNASISRQKPADATEGRNALTAVGTCFAHTTLDYVANINIAHAHKDHMILDALWTLVR 210

  Fly   198 ACVTYYHQGFDLCNDFDEFFK----NISEDLNALRGDYQQLEKAMQNRHMSVNRYCDSNTNSTSN 258
            ....::.:|.   ..|||:..    .|::.:.......:.:|:.||:.|..|.:....:.:....
Worm   211 ESSAFFSKGH---ATFDEWTAADNGAIADTIQTFAAKSKLIERKMQDVHSLVPKEMFQHPSGMPI 272

  Fly   259 K----IEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNE-DSFSVMEEDLRICSVRPVNEG-D 317
            :    :||||:|:.|..||||.||||.:.|.||:|..||.: :..::|||:||||.|||.... |
Worm   273 EPDVMMEGYLYKRSSNAFKTWNRRWFQIKDKQLLYSHRSTDLEPATIMEENLRICLVRPAPSNID 337

  Fly   318 RRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDST--------------------- 361
            |..|||:::||:.|:|||||..:...|:.|||.:|.|..:.||.
Worm   338 RIGCFELVTPTRIHLLQADSESLCQDWMRALQRTILALHEGDSVDVASTSPRNKTTSMSSGVTLT 402

  Fly   362 ------------------HHSRPQS--TNAPNNSLP-----AKRRIHWEEFLKIPGNAYCCDCRS 401
                              ..|.|.|  |:|..:|:.     :.....:|:..::|||..|.||.|
Worm   403 SANAISPLSNAMDVTKGRSVSDPASTYTSANTSSISTAAGFSSSTTAFEQVRRVPGNEVCADCGS 467

  Fly   402 PEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIG 466
            |.|:|.|||||:.|||||||.||||||..||||||.:|:.::|...|::.|||..||.|:.|.:.
Worm   468 PAPKWVSINLGVVLCIECSGAHRSLGVQTSKVRSLCMDSIDNELRDVLLALGNRQVNEIFLAHLP 532

  Fly   467 DDCGLKKP--TEQCEIGVREAWIKAKYVERRFV--------CGMPKPQELLASETAEVLSIDSGG 521
            ....:..|  .|:.....||||||||||||||.        ......||.|..:|:...:..|.|
Worm   533 PADSIVPPQINEKSARPAREAWIKAKYVERRFAVAEDTRARSSATNRQEHLKHKTSIGGNSSSNG 597

  Fly   522 V--------VEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTG 578
            |        |:|.||||                                 .|..||.
Worm   598 VNRSSSYADVQDAESGG---------------------------------LLDADPW-------- 621

  Fly   579 DELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPF 643
                  ..|.|:.:|:.|..:|     ..|.|..||.:.:..|   |.::.:.:|..|:.|
Worm   622 ------SADLSVPVPTASKRLS-----ACGSDTNLDAIGSSSI---DTKTVEWDSVKEACE---- 668

  Fly   644 SQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAA 708
                          ..:|..:..|:|.|.|   .|......:.||.|..:|...|.||||||||.
Worm   669 --------------CGDLLALMTAYAQGFD---LNALHNGTTALHIATRNGQTAAVEFLLLNGAK 716

  Fly   709 IDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQL 773
            |:.:||...:.||::..:||...|..|||..|..:|::.|.|..||||::..:||||||.|:|.:
Worm   717 INMLDEKLNTPLHLAAKEGHTLPVCQLLKRGADSNLANVDSKTPLDIAMECTHADIVTLFRVTIM 781

  Fly   774 NDEIGPNDEYNGE-DETYKNVMKDFSKLPASQTRVLRQRHDSNTLES 819
            .::.  |.::|.. |||.:.|:.|.::..|::    :::..:.:|:|
Worm   782 RNDF--NADFNNPMDETVEAVISDIARRAATE----KEQKKTESLKS 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	58/200 (29%)
		PH	259..352	CDD:278594	47/98 (48%)
		PH_ACAP	260..355	CDD:270070	48/96 (50%)
		ArfGap	384..497	CDD:279720	60/114 (53%)
		ANK	652..768	CDD:238125	43/115 (37%)
		Ank_4	683..736	CDD:290365	21/52 (40%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
cnt-1	NP_001369802.1	BAR_ACAPs	30..233	CDD:153287	58/206 (28%)
		PH_ACAP	278..377	CDD:270070	49/98 (50%)
		ArfGap_ACAP	447..565	CDD:350064	60/117 (51%)
		PTZ00322	628..>795	CDD:140343	60/197 (30%)
		ANK repeat	690..721	CDD:293786	14/30 (47%)
		Ank_2	695..775	CDD:403870	36/79 (46%)
		ANK repeat	723..754	CDD:293786	10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I3479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8182
Inparanoid	1	1.050	347	1.000	Inparanoid score	I1360
Isobase	1	0.950	-	0	Normalized mean entropy	S2927
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		oto20802
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	LDO	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.960