DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and Acap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_997106.1	Gene:	Acap3 / 140500	MGIID:	2153589	Length:	833	Species:	Mus musculus

Alignment Length:	867	Identity:	310/867 - (35%)
Similarity:	472/867 - (54%)	Gaps:	116/867 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            |:|||||:|||||||..:.:.|:|:..:|.:|:|::|||:..:::||.||.....|...:.||.|
Mouse     2 TVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQ 66

  Fly    69 HFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEG 133
            ....:......|.:.....|||..:||||.|||.|:|.:.|..|||:|:.:.|:.|..|.||.|.
Mouse    67 QCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRSVRQQLHNFVKEDVRKFKETKKQFDKVRED 131

  Fly   134 YDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQA 198
            .:.:|::||||.::||.|::||...|:.::.||:|.|||||..|.:.||:|...||.::|.:..|
Mouse   132 MELSLVRNAQAPRHRPHEVEEATGALTVTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHA 196

  Fly   199 CVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR------------YCDS 251
            ..:::.||:.|.:..|.:.|.::.:|:.|..|....::.|:.:|.::.:            ..:.
Mouse   197 QYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEF 261

  Fly   252 NTNSTSNKI-EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNE 315
            :.::.|..: ||||||:.|..||||.||||.:.::||||:|:. :|:.:|:.:|||:|||:|..:
Mouse   262 DVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKL-KDALTVVVDDLRLCSVKPCED 325

  Fly   316 GDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH--DSTHHSRPQSTNAPNNSL-- 376
            .:|||||||:|||||.:|||||..:...|:.|:|.||.:|.:.  ||.:..|...|.:|:.|.
Mouse   326 IERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390

  Fly   377 ----PAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKV 433
                ..:|.:..|..|:    :.||:.|.||..|:|||||||||:.|||||||:|||||||.|||
Mouse   391 STTDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKV 455

  Fly   434 RSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVC 498
            ||||||:||.|.:|:|.||||..||:||||:. :..|::|||.......:|||||.||||::|:
Mouse   456 RSLTLDSWEPELLKLMCELGNSTVNQIYEAQC-EGPGVRKPTASSSRQDKEAWIKDKYVEKKFL- 518

  Fly   499 GMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRR--------- 554
                 ::|.::...|                             ..|:|..:|.:|
Mouse   519 -----RKLTSAPARE-----------------------------PPRRWRAQKCQRPHSSPHAPT 549

  Fly   555 -RQKQRSIPKTLSDDPSI--YNTAKT------GDELEDDDDDESI--------------NIPSMS 596
             |:|.|..|..    ||:  .::|.|      .|.|...|:.:|:              ::.|.|
Mouse   550 TRRKVRLEPVL----PSVAALSSAATMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDS 610

  Fly   597 -LSISRD---DLLVIGDDLALDRL-ETPGILGSDQES-TDGESDAESPEELPFSQLDANQLLYMA 655
             |..|.|   |:|..|....:|.: |..|....:..| .|||::|.|..::  .:|....|.:.|
Mouse   611 GLGGSSDGSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADV--RELHPGLLAHQA 673

  Fly   656 SVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSAL 720
            :...:||.:..|.|.||:..|.:..|..::.|.|||:.||::.|||||.|||.::..|.:|.:.|
Mouse   674 ARTRDLPALAAALAHGAEVNWADAADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPL 738

  Fly   721 HISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEI-------- 777
            |.:|..|...||.|.||..|.......:.:..|.|||...||||||||||.::.:|:
Mouse   739 HHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREAEAPPG 803

  Fly   778 --GPNDEYNGEDETYKNVMKDF 797
              ||....:..:..|:..:::|
Mouse   804 QPGPLPGSSPTELQYRRCIQEF 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	72/198 (36%)
		PH	259..352	CDD:278594	49/93 (53%)
		PH_ACAP	260..355	CDD:270070	51/95 (54%)
		ArfGap	384..497	CDD:279720	68/116 (59%)
		ANK	652..768	CDD:238125	45/115 (39%)
		Ank_4	683..736	CDD:290365	23/52 (44%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	11/30 (37%)
Acap3	NP_997106.1	BAR_ACAP3	16..215	CDD:153321	72/198 (36%)
		PH	269..363	CDD:278594	50/94 (53%)
		PH_ACAP	271..367	CDD:270070	52/96 (54%)
		ArfGap	403..521	CDD:279720	69/124 (56%)
		ANK	671..786	CDD:238125	45/114 (39%)
		Ank_2	671..764	CDD:289560	35/92 (38%)
		ANK repeat	700..731	CDD:293786	14/30 (47%)
		ANK repeat	733..764	CDD:293786	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3233
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1377
Isobase	1	0.950	-	0	Normalized mean entropy	S2927
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm43002
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	LDO	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820