DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and Asap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_006520455.1	Gene:	Asap1 / 13196	MGIID:	1342335	Length:	1223	Species:	Mus musculus

Alignment Length:	855	Identity:	200/855 - (23%)
Similarity:	314/855 - (36%)	Gaps:	237/855 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SDIEHLEQ---RLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFL--DNKNAHNALGKLIH 85
            |..|.|:|   .|:|:.|......:||:::|:|:..:|..|.....:||  ||.:...|..|...
Mouse   135 SSFEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFST 199

  Fly    86 CFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVK-DYKGHFLKVSEGYDNALIKNAQASKNRP 149
            ..:|::.....||...|..|:..|...:|.|:..|| |.|..|.|..:.|:....|..:..:...
Mouse   200 LTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHA 264

  Fly   150 QEM---------QEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQACVTYYHQ 205
            ::.         .|.|..:...:..||....:|:..:...:.:|...:|..|:.||.|...::..
Mouse   265 KQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQD 329

  Fly   206 GFDLCNDFDEFFKNISED--------------LNALR--------------GDYQQLEKAMQNRH 242
            |....:...::.:.::.|              |.|||              |......:|..:|.
Mouse   330 GLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDPKEVGGLYVASRANSSRR 394

  Fly   243 MSVNR-------YCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQL-VYRKRSNEDSFS 299
            .|.:|       ....|....|.| :|:|.||.....|.|.||...:.:..| :....||.....
Mouse   395 DSQSRQGGYSMHQLQGNKEYGSEK-KGFLLKKSDGIRKVWQRRKCAVKNGILTISHATSNRQPAK 458

  Fly   300 VMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHS 364
            :   :|..|.|:| |..|:: .|::||..:::..||:.......|||.|.:|...|:   :....
Mouse   459 L---NLLTCQVKP-NAEDKK-SFDLISHNRTYHFQAEDEQDYIAWISVLTNSKEEAL---TMAFR 515

  Fly   365 RPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVH 429
            ..|||.  .|||....:...|:..::|||..||||.|.||.|.|.||||..||||||:||.:|||
Mouse   516 GEQSTG--ENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVH 578

  Fly   430 YSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVER 494
            .|:::||.||...:..:.:...:||...|.|.||.:....  .|||...::.||:.:|.||||:.
Mouse   579 ISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPS--PKPTPSSDMTVRKEYITAKYVDH 641

  Fly   495 RFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQR 559
            ||                                               :||....
Mouse   642 RF-----------------------------------------------SRKTCAS--------- 650

  Fly   560 SIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGS 624
                         ::||..:.||               :|...||      |||.::...|:
Mouse   651 -------------SSAKLNELLE---------------AIKSRDL------LALIQVYAEGV--- 678

  Fly   625 DQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQ 689
                           ||....|:..|                  .||            .:.||.
Mouse   679 ---------------ELMEPLLEPGQ------------------ELG------------ETALHL 698

  Fly   690 AVISG---SVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKK 751
            ||.:.   |:...:||:.|...:|....:|.:.||..:..|....:.|||:.|...|:.:.:|:.
Mouse   699 AVRTADQTSLHLVDFLVQNCGNLDKQTSVGNTVLHYCSMYGKPECLKLLLRSKPTVDIVNQNGET 763

  Fly   752 ALDIAVDQENADIVTLLRLTQLND--------EIGPN-----------DEYNGEDETYKN----V 793
            |||||         ..|:.||..|        :..|:           ||.:..|:...:    :
Mouse   764 ALDIA---------KRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQDEMDESDDDLDDKPSPI 819

  Fly   794 MKDFSKLPAS 803
            .|:.|..|.|
Mouse   820 KKERSPRPQS 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	47/205 (23%)
		PH	259..352	CDD:278594	27/93 (29%)
		PH_ACAP	260..355	CDD:270070	27/95 (28%)
		ArfGap	384..497	CDD:279720	50/112 (45%)
		ANK	652..768	CDD:238125	26/118 (22%)
		Ank_4	683..736	CDD:290365	14/55 (25%)
		ANK repeat	687..713	CDD:293786	9/28 (32%)
		ANK repeat	715..746	CDD:293786	9/30 (30%)
Asap1	XP_006520455.1	BAR_ASAP1	138..344	CDD:153325	46/205 (22%)
		PH_ASAP	407..513	CDD:270071	31/114 (27%)
		ArfGap_ASAP1	528..649	CDD:350073	53/169 (31%)
		ANK repeat	692..725	CDD:293786	10/44 (23%)
		Ank_2	696..>768	CDD:372319	22/71 (31%)
		ANK repeat	727..758	CDD:293786	9/30 (30%)
		Atrophin-1	845..>1109	CDD:367360
		SH3_ASAP1	1165..1221	CDD:212898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820