DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and AGAP3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_114152.3	Gene:	AGAP3 / 116988	HGNCID:	16923	Length:	911	Species:	Homo sapiens

Alignment Length:	234	Identity:	77/234 - (32%)
Similarity:	123/234 - (52%)	Gaps:	21/234 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 EGDRRFCFEVISPT-KSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNNSLPA 378
            |.:..|.|.|:|.| ::...:|.:|:...||:.::|..|.|::|  ....::.::.....|:..|
Human   602 EAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQ--GCRSAKDKTRLGNQNAALA 664

  Fly   379 KRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWES 443
            .:.:.     .:.||::|.||.:|.|.|||:|||..:||||||:||.||.|.|:||||.||.|..
Human   665 VQAVR-----TVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPP 724

  Fly   444 ENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKP----- 503
            |.:.||..:||.:.|.::|..:|   |..||........:|.||:|||.::.|:..:|..
Human   725 ELLAVMTAMGNALANSVWEGALG---GYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLG 786

  Fly   504 QELLASETAE-----VLSIDSGGVVEDGESGGSGIAKRA 537
            |:||.:...:     |:.:..|...|..|:.|.|..:.|
Human   787 QQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTA 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594	11/37 (30%)
		PH_ACAP	260..355	CDD:270070	12/40 (30%)
		ArfGap	384..497	CDD:279720	49/112 (44%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
AGAP3	NP_114152.3	small_GTPase	126..291	CDD:197466
		Centaurin_gamma	128..285	CDD:133303
		PH_AGAP	401..645	CDD:241281	13/42 (31%)
		PH	404..>465	CDD:278594
		ArfGap	664..778	CDD:279720	51/121 (42%)
		Ank_2	789..879	CDD:289560	9/37 (24%)
		ANK	789..>878	CDD:238125	9/37 (24%)
		ANK repeat	789..819	CDD:293786	6/29 (21%)
		ANK repeat	821..852	CDD:293786	1/5 (20%)
		ANK repeat	854..879	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850