DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and AGAP2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001116244.1	Gene:	AGAP2 / 116986	HGNCID:	16921	Length:	1192	Species:	Homo sapiens

Alignment Length:	273	Identity:	82/273 - (30%)
Similarity:	126/273 - (46%)	Gaps:	52/273 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 STSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRR 319
            :|.:|.||...:.::|                   ||.....||.         |:|.:.:.:..
Human   839 TTPSKTEGSAGQAEAK-------------------RKMWKLKSFG---------SLRNIYKAEEN 875

  Fly   320 FCFEVISPT-KSHILQADSADMLSLWISALQHSIGAAIQ--HDSTHHSRPQSTNAPNNSLPAKRR 381
            |.|.::|.| ::...:|.|.:....|:.|::..|.|::|  ..|....|..|.:         ..
Human   876 FEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQS---------EA 931

  Fly   382 IHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENV 446
            :..:......||:.|.||.:|.|.|||:|||..:||||||:||:||.|.|:||||.||.|..|..
Human   932 VAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELT 996

  Fly   447 KVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELL---- 507
            .|:..:||:..||::|:   |..|..||:.......||:||:|||.:..|:..:...:|.|
Human   997 LVLTAIGNDTANRVWES---DTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQL 1058

  Fly   508 -----ASETAEVL 515
                 |.:.|.||
Human  1059 WAAVQAQDVATVL 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594	18/93 (19%)
		PH_ACAP	260..355	CDD:270070	18/95 (19%)
		ArfGap	384..497	CDD:279720	50/112 (45%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
AGAP2	NP_001116244.1	Interaction with EPB41L1. /evidence=ECO:0000250	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..377
		Interactions with HOMER1 and NF2. /evidence=ECO:0000250	180..225
		Interaction with PLCG1. /evidence=ECO:0000250	267..390
		G domain	405..572
		small_GTPase	405..572	CDD:197466
		Centaurin_gamma	407..566	CDD:133303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..619
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..673
		PH_AGAP	674..914	CDD:241281	21/102 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..854		4/14 (29%)
		PH	<845..909	CDD:278594	17/91 (19%)
		ArfGap	933..1047	CDD:279720	51/116 (44%)
		Ank_2	1058..1148	CDD:289560	4/14 (29%)
		ANK	1058..>1147	CDD:238125	4/14 (29%)
		ANK repeat	1058..1088	CDD:293786	4/14 (29%)
		ANK repeat	1090..1121	CDD:293786
		ANK 1	1090..1119
		ANK 2	1123..1152
		ANK repeat	1123..1148	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1192
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820