DRSC/TRiP Functional Genomics Resources

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Protein Alignment CenB1A and ARAP1

DIOPT Version :9

Sequence 1:NP_524458.1 Gene:CenB1A / 42735 FlyBaseID:FBgn0039056 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_001035207.1 Gene:ARAP1 / 116985 HGNCID:16925 Length:1450 Species:Homo sapiens


Alignment Length:582 Identity:137/582 - (23%)
Similarity:223/582 - (38%) Gaps:125/582 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   309 SVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPN 373
            ||..|.|.||| .|::.:|.:.....|||......|:.|:|.:|..|:           ||:   
Human   486 SVGNVKEVDRR-SFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEAL-----------STS--- 535

  Fly   374 NSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTL 438
               ....|| |    ....|.:|.||.:|:|.||||||.:.:|..|:|.||.||...||||||.:
Human   536 ---EVAERI-W----AAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKM 592

  Fly   439 D--AWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVE---RRF-- 496
            |  .|....:::.::|||...||.:.|.:.....|:..:..   ..|...::|||.|   ||:  
Human   593 DRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSP---STRRCHLEAKYREGKYRRYHP 654

  Fly   497 -----------VCGMPKPQELLASETAEVLSIDSGGVVEDGESGGS---GIAKRA--TLSLGGTR 545
                       :|......:|  :||..:|...:|.....|:....   .:|::|  ||.:...|
Human   655 LFGNQEELDKALCAAVTTTDL--AETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLR 717

  Fly   546 KWAVKKLRRRQKQRSIPK-------TLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDD 603
            .....::.|....:.:.|       |:|....:|.||..|..|:|....|         ..|| .
Human   718 NNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRARE---------EFSR-R 772

  Fly   604 LLVIGDDLAL----DRLETPGILGSDQESTDGESDAES--------PE----ELPFSQLDANQLL 652
            ..|:||.:..    :|..||          :||..|..        |:    |..|......:.|
Human   773 WCVLGDGVLSYFENERAVTP----------NGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERL 827

  Fly   653 YM-----ASVVHNLPVMCMAFALG---ADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAI 709
            |:     |...|.. |.|:|.|..   |:.:.....:|.....::|.:|.......:..|:|:.:
Human   828 YLFGLESAEQAHEW-VKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSEL 891

  Fly   710 DAV-------DEMGYSALHISTAKGHIA-QVYLLLKHKAAYDLSSSDGKKALDI-----AVDQEN 761
            .||       :.:....|...:.:|... ||.:|::.:....:   .|::.||.     |:.:..
Human   892 RAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYI---QGERRLDFMGWLGAIQKAA 953

  Fly   762 ADIVTLLRLTQLNDEIGPNDEYNGEDE------TYKNVMKDFSKLPASQTRVLRQRHDSNTL 817
            |.:...|...||.|...|...|...|.      |.:.:.:...:...:|..:...|.|:.::
Human   954 ASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSV 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CenB1ANP_524458.1 BAR_ACAPs 18..217 CDD:153287
PH 259..352 CDD:278594 15/42 (36%)
PH_ACAP 260..355 CDD:270070 16/45 (36%)
ArfGap 384..497 CDD:279720 42/130 (32%)
ANK 652..768 CDD:238125 26/136 (19%)
Ank_4 683..736 CDD:290365 10/60 (17%)
ANK repeat 687..713 CDD:293786 6/32 (19%)
ANK repeat 715..746 CDD:293786 5/31 (16%)
ARAP1NP_001035207.1 SAM_Arap1,2,3 6..68 CDD:188889
SAM 10..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..144
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..302
PH 328..419 CDD:278594
PH1_ARAP 329..421 CDD:270073
PH2_ARAP 436..525 CDD:270074 14/39 (36%)
ArfGap 535..651 CDD:279720 42/129 (33%)
PH3_ARAP 743..849 CDD:270076 30/126 (24%)
PH 744..848 CDD:278594 29/124 (23%)
PH4_ARAP 862..952 CDD:270077 16/92 (17%)
RhoGAP_ARAP 956..1135 CDD:239850 11/60 (18%)
RA 1172..1261 CDD:279168
PH5_ARAP 1263..1402 CDD:270079
PH 1299..1391 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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