DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and ACAP3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_011538908.1	Gene:	ACAP3 / 116983	HGNCID:	16754	Length:	844	Species:	Homo sapiens

Alignment Length:	858	Identity:	308/858 - (35%)
Similarity:	465/858 - (54%)	Gaps:	81/858 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            |:|||||:|||||||..:.:.|:|:..:|.:|:|::|||:..|::||.||.....|...:.||.|
Human     2 TVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQ 66

  Fly    69 HFLDN----------KNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDY 123
            ....:          .:....|.:.....||:..:|.||.|||.|:|.:.|..|||:|:.:.|:.
Human    67 QCQGDTVISVRGRLTSDLKECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKET 131

  Fly   124 KGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSI 188
            |..|.||.|..:.:|::||||.::||.|::||...|:.::.||:|.|||||..|.:.||:|...|
Human   132 KKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEI 196

  Fly   189 LSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR------ 247
            |.::|.:..|..:::.||:.|.:..|.:.|.::.:|:.|..|....::.|:.:|.::.:
Human   197 LDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQD 261

  Fly   248 --YCDS----NTNSTSNKI-EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDL 305
              |.:|    :.::.|..: ||||||:.|..||||.||||.:.::||||:|:. :|:.:|:.:||
Human   262 FSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKL-KDALTVVVDDL 325

  Fly   306 RICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH--DSTHHSRPQS 368
            |:|||:|..:.:|||||||:|||||.:|||||..:...|:.|:|.||.:|.:.  ||.:..|...
Human   326 RLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDR 390

  Fly   369 TNAPNNSL------PAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVH 423
            |.:|:.|.      ..:|.:..|..|:    :.||:.|.||..|:|||||||||:.|||||||:|
Human   391 TASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIH 455

  Fly   424 RSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIK 488
            ||||||.|||||||||:||.|.:|:|.||||..||:||||:. :..|.:|||.......:|||||
Human   456 RSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQC-EGAGSRKPTASSSRQDKEAWIK 519

  Fly   489 AKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKR-----------ATLSLG 542
            .||||::|:...|....|.|.....|..     .:....|..:..|:|           |.||..
Human   520 DKYVEKKFLRKAPMAPALEAPRRWRVQK-----CLRPHSSPRAPTARRKVRLEPVLPCVAALSSV 579

  Fly   543 GTRKWAVKKLRRRQKQRSI--PKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLL 605
            ||       |.|:.::.|:  |..|....|.::....|........|..:.    ..|....|:|
Human   580 GT-------LDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLG----GSSDGSSDVL 633

  Fly   606 VIGDDLALDRLETPGILGSDQESTDGESDAESPEE----LPFSQLDANQLLYMASVVHNLPVMCM 666
            ..|....:|.:....  |::.|.:.||:|.::..|    ....:|....|.:.|:...:||.:..
Human   634 AFGSGSVVDSVTEEE--GAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAA 696

  Fly   667 AFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQ 731
            |.|.||:..|.:.:|..::.|.|||:.||::.|||||.|||.::..|..|.:.||.:|..|...|
Human   697 ALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQ 761

  Fly   732 VYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEI-------GPNDEYNGE--D 787
            |.|.||..|.......:.:..|.|||...||||||||||.::.:|:       ||.....|.  :
Human   762 VCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTE 826

  Fly   788 ETYKNVMKDFSKL 800
            ..::..:::|..|
Human   827 LQFRRCIQEFISL 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	71/208 (34%)
		PH	259..352	CDD:278594	49/93 (53%)
		PH_ACAP	260..355	CDD:270070	51/95 (54%)
		ArfGap	384..497	CDD:279720	68/116 (59%)
		ANK	652..768	CDD:238125	45/115 (39%)
		Ank_4	683..736	CDD:290365	23/52 (44%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	11/30 (37%)
ACAP3	XP_011538908.1	BAR	16..225	CDD:299863	71/208 (34%)
		PH	279..373	CDD:278594	50/94 (53%)
		PH_ACAP	281..377	CDD:270070	52/96 (54%)
		ArfGap	413..531	CDD:279720	69/118 (58%)
		ANK	711..>798	CDD:238125	37/86 (43%)
		ANK repeat	712..743	CDD:293786	14/30 (47%)
		Ank_4	715..766	CDD:290365	23/50 (46%)
		ANK repeat	745..776	CDD:293786	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3294
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1188
Isobase	1	0.950	-	0	Normalized mean entropy	S2927
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm40931
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	LDO	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820