Protein Alignment CenB1A and ACAP3

DIOPT Version :10

• Sequence 1: NP_524458.1
• Gene: CenB1A / 42735
• FlyBaseID: FBgn0039056
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_011538908.1
• Gene: ACAP3 / 116983
• HGNCID: 16754
• Length: 844
• Species: Homo sapiens
• Alignment Length: 858
• Identity: 308/858 - (35%)
• Similarity: 465/858 - (54%)
• Gaps: 81/858 - (9%)

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            |:|||||:|||||||..:.:.|:|:..:|.:|:|::|||:..|::||.||.....|...:.||.|
Human     2 TVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQ 66

  Fly    69 HFLDN----------KNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDY 123
            ....:          .:....|.:.....||:..:|.||.|||.|:|.:.|..|||:|:.:.|:.
Human    67 QCQGDTVISVRGRLTSDLKECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKET 131

  Fly   124 KGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSI 188
            |..|.||.|..:.:|::||||.::||.|::||...|:.::.||:|.|||||..|.:.||:|...|
Human   132 KKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEI 196

  Fly   189 LSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR------ 247
            |.::|.:..|..:::.||:.|.:..|.:.|.::.:|:.|..|....::.|:.:|.::.:
Human   197 LDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQD 261

  Fly   248 --YCDS----NTNSTSNKI-EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDL 305
              |.:|    :.::.|..: ||||||:.|..||||.||||.:.::||||:|:. :|:.:|:.:||
Human   262 FSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKL-KDALTVVVDDL 325

  Fly   306 RICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH--DSTHHSRPQS 368
            |:|||:|..:.:|||||||:|||||.:|||||..:...|:.|:|.||.:|.:.  ||.:..|...
Human   326 RLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDR 390

  Fly   369 TNAPNNSL------PAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVH 423
            |.:|:.|.      ..:|.:..|..|:    :.||:.|.||..|:|||||||||:.|||||||:|
Human   391 TASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIH 455

  Fly   424 RSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIK 488
            ||||||.|||||||||:||.|.:|:|.||||..||:||||:. :..|.:|||.......:|||||
Human   456 RSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQC-EGAGSRKPTASSSRQDKEAWIK 519

  Fly   489 AKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKR-----------ATLSLG 542
            .||||::|:...|....|.|.....|..     .:....|..:..|:|           |.||..
Human   520 DKYVEKKFLRKAPMAPALEAPRRWRVQK-----CLRPHSSPRAPTARRKVRLEPVLPCVAALSSV 579

  Fly   543 GTRKWAVKKLRRRQKQRSI--PKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLL 605
            ||       |.|:.::.|:  |..|....|.::....|........|..:.    ..|....|:|
Human   580 GT-------LDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLG----GSSDGSSDVL 633

  Fly   606 VIGDDLALDRLETPGILGSDQESTDGESDAESPEE----LPFSQLDANQLLYMASVVHNLPVMCM 666
            ..|....:|.:....  |::.|.:.||:|.::..|    ....:|....|.:.|:...:||.:..
Human   634 AFGSGSVVDSVTEEE--GAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAA 696

  Fly   667 AFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQ 731
            |.|.||:..|.:.:|..::.|.|||:.||::.|||||.|||.::..|..|.:.||.:|..|...|
Human   697 ALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQ 761

  Fly   732 VYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEI-------GPNDEYNGE--D 787
            |.|.||..|.......:.:..|.|||...||||||||||.::.:|:       ||.....|.  :
Human   762 VCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTE 826

  Fly   788 ETYKNVMKDFSKL 800
            ..::..:::|..|
Human   827 LQFRRCIQEFISL 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	71/208 (34%)
		PH_ACAP	260..355	CDD:270070	51/95 (54%)
		ArfGap_ACAP	381..497	CDD:350064	68/119 (57%)
		ANKYR	<647..>768	CDD:440430	46/120 (38%)
		ANK repeat	687..713	CDD:293786	14/25 (56%)
		ANK repeat	715..746	CDD:293786	11/30 (37%)
ACAP3	XP_011538908.1	BAR	16..225	CDD:472257	71/208 (34%)
		PH_ACAP	281..377	CDD:270070	52/96 (54%)
		ArfGap_ACAP3	413..528	CDD:350075	68/115 (59%)
		ANKYR	<711..>798	CDD:440430	37/86 (43%)
		ANK repeat	712..743	CDD:293786	14/30 (47%)
		ANK repeat	745..776	CDD:293786	11/30 (37%)