DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and LOC110438288

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_021325325.1	Gene:	LOC110438288 / 110438288	-ID:	-	Length:	569	Species:	Danio rerio

Alignment Length:	591	Identity:	221/591 - (37%)
Similarity:	308/591 - (52%)	Gaps:	110/591 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 IEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNEGDRRFCFEV 324
            :||||||:.|..||||.||||.:.:|||||:|:. :|:.:|:.||||:|:|:...:.:|||||||
Zfish    34 MEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKF-KDNPTVVVEDLRLCTVKHCEDIERRFCFEV 97

  Fly   325 ISPTKSHILQADSADMLSLWISALQHSIGAAIQ---HDSTHHSRPQSTNAPNNSLPA-----KRR 381
            :|||||.::||||..:...||.|:|:||..|.:   .|:....|..||:  ..||.:     ::.
Zfish    98 VSPTKSCMMQADSEKLRQAWIKAVQNSIATAFRDKADDAEKMDRKSSTS--TGSLDSAGDVKEKC 160

  Fly   382 IHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKVRSLTLDAWE 442
            :..|..|:    |.||:.||||..||||||||||||||||:|||:|||||||:|||||||||.||
Zfish   161 VKGENALQRVMAISGNSSCCDCGQPEPRWASINLGITLCIQCSGIHRSLGVHFSKVRSLTLDTWE 225

  Fly   443 SENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELL 507
            .|.:|:|.||||.|:|:||||| .::.|.:||.........||:|||||||||||      |...
Zfish   226 PELLKLMCELGNGVINQIYEAR-REELGARKPNAGDPRHEVEAYIKAKYVERRFV------QRRS 283

  Fly   508 ASETAE-VLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPK-TLSDDPS 570
            ..|..: ||.:..    ||....|..                     ..|..||:.| .|:...|
Zfish   284 EDEIRQKVLLLSK----EDKHPSGCS---------------------DTQTTRSVSKPRLASSSS 323

  Fly   571 IY-NTAKTGDELED-------------------------DDDDESINIPSMSLSISRDDLLVIGD 609
            :: .:....|||:.                         ::..|::|..:.:.:::.
Zfish   324 VHLESLFCVDELDSLFSYFTSSGQTRCLRSSDGEAQTLTEESRETVNASASTSTVNH-------- 380

  Fly   610 DLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADK 674
                          :|:|...|::.....|.   .|..|...||.||...:||.|..|.|.||..
Zfish   381 --------------TDEEGCCGKAVVVFCEP---QQATAGLQLYWASFSRSLPDMAEALAHGAQV 428

  Fly   675 MWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHK 739
            .|.|.:...|:.|..||..||::.|||||.|.|:::.:|..|...||.:|..||..||.|.||..
Zfish   429 NWTNTEQDNRTPLIMAVHGGSLVTCEFLLQNSASVNQLDSWGRGPLHHATILGHTGQVCLFLKRG 493

  Fly   740 AAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEI----GP---NDEYNGEDET---YKNVM 794
            |..:.:..:.:..|.|||:..||||||||||.::|:|:    ||   :.:|:....|   |:..|
Zfish   494 ANQNAADVENQTPLSIAVEAANADIVTLLRLAKMNEEMRESEGPYSQSGQYHSNSPTELQYRKCM 558

  Fly   795 KDFSKL 800
            ::|..|
Zfish   559 EEFITL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594	49/91 (54%)
		PH_ACAP	260..355	CDD:270070	51/94 (54%)
		ArfGap	384..497	CDD:279720	74/116 (64%)
		ANK	652..768	CDD:238125	49/115 (43%)
		Ank_4	683..736	CDD:290365	23/52 (44%)
		ANK repeat	687..713	CDD:293786	12/25 (48%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
LOC110438288	XP_021325325.1	PH_ACAP	34..130	CDD:270070	52/96 (54%)
		ArfGap	164..282	CDD:307528	77/124 (62%)
		ANK	406..522	CDD:238125	49/115 (43%)
		ANK repeat	406..432	CDD:293786	12/25 (48%)
		ANK repeat	436..467	CDD:293786	13/30 (43%)
		ANK repeat	469..500	CDD:293786	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010