DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and asap2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_002935078.3	Gene:	asap2 / 100494274	XenbaseID:	XB-GENE-1002636	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	817	Identity:	162/817 - (19%)
Similarity:	304/817 - (37%)	Gaps:	225/817 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SPRFRQFVSK------------EESDIEH-LEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            ||....|.::            |..:::| :..:::|.:|..:.   ||..:|:|:..:..:|..
Frog    20 SPTASNFTNRLSQCRNTVVAIDEALEVDHTILNKMKKSVKAIHT---SGLTHVENEEQYTQALEK 81

  Fly    66 LQQHFL--DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVK-DYKGHF 127
            ...:.:  |:.:...|..|.....:|:......|:...:..:...|...:|.|:..|| :.|..|
Frog    82 FGSNCVCRDDPDLGTAFLKFSVFTKELTALFKNLVQNMNNIITFPLDSLLKGDLKGVKGELKKPF 146

  Fly   128 LKVSEGYDNALIKNAQASKNRPQ-------EMQ--EAANILSASKSCFQHTALDYVNYITLAQAR 183
            .|..:.|:..:.|..:..|...:       |:.  |.|..:...:..||....:|:..:...:.:
Frog   147 EKAWKDYETKVTKIEKEKKEHAKMHGMIRTEISGAEIAEEMEKERRVFQLQMCEYLLKVNEIKIK 211

  Fly   184 KVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRG------------------- 229
            |...:|..|:.|:.|...::..|...........:.:|.||:.::.
Frog   212 KGVDLLQNLIKYFHAQCNFFQDGLKAVETLKPSIEKLSTDLHTIKQVQDEERKQLSQLRDILKAA 276

  Fly   230 -DYQQLEKAMQNRHMSVNRYCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRS 293
             ..:|.|.:...:.::.:.:.........::.:|||:||.....|.|.:            ||.:
Frog   277 LQVEQKEDSQIRQSVAYSLHQPQGNKEHGSERDGYLYKKSDGIRKVWQK------------RKCT 329

  Fly   294 NEDSFSVMEE----------DLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISAL 348
            .::.|..:..          :|..|.|: .|..::: .|::||..:::..||:......:|:|.|
Frog   330 VQNGFLTISHGTANIPPAKLNLLTCQVK-TNPEEKK-SFDLISHDRTYHFQAEDETECQIWMSVL 392

  Fly   349 QHS----IGAAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASI 409
            |:|    :..|.:.|   ||..:     ||.:....:....:..::|||..||||.:.:|.|.|.
Frog   393 QNSKEEALNNAFKGD---HSAGE-----NNIVQELTKEIISDIQRMPGNDVCCDCGASDPTWLST 449

  Fly   410 NLGITLCIECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKP 474
            ||||..||||||:||.||||||:::|||||...:..:.:...:||...|.:.||.:..|..: ||
Frog   450 NLGILTCIECSGIHRELGVHYSRIQSLTLDVLGTSELLLAKNIGNSGFNELMEACLPADDSV-KP 513

  Fly   475 TEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATL 539
            :...::..|:.:|..||:||::.
Frog   514 SPCSDMNARKDYITTKYIERKYA------------------------------------------ 536

  Fly   540 SLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDL 604
                         ||:                |:             |.:..:..:..::...|:
Frog   537 -------------RRK----------------YH-------------DNASKLHGLCDAVKSRDI 559

  Fly   605 LVIGDDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFA 669
                  ..|.:|...|:     :.|:|         :|.:
Frog   560 ------FTLVQLHAEGV-----DLTEG---------IPLA------------------------- 579

  Fly   670 LGADKMWKNPQDRQRSFLHQAVIS---GSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQ 731
                    |..::..:.||.||.|   .|:...:||:.|...:|.....|.:|||......:...
Frog   580 --------NGHEQGETALHLAVRSVDRNSLHIVDFLVQNSGNLDKQTAKGSTALHYCCLTDNAEC 636

  Fly   732 VYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLL 768
            :.|||:.||:.|:::..|:..||||...::|....||
Frog   637 LKLLLRGKASTDIANDAGETPLDIAKRLKHAQCEDLL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	38/223 (17%)
		PH	259..352	CDD:278594	24/106 (23%)
		PH_ACAP	260..355	CDD:270070	24/108 (22%)
		ArfGap	384..497	CDD:279720	47/112 (42%)
		ANK	652..768	CDD:238125	27/118 (23%)
		Ank_4	683..736	CDD:290365	15/55 (27%)
		ANK repeat	687..713	CDD:293786	10/28 (36%)
		ANK repeat	715..746	CDD:293786	10/30 (33%)
asap2	XP_002935078.3	BAR_ASAP2	34..248	CDD:153326	37/216 (17%)
		PH_ASAP	297..403	CDD:270071	24/119 (20%)
		ArfGap_ASAP2	419..541	CDD:350074	49/193 (25%)
		ANKYR	498..676	CDD:223738	52/314 (17%)
		ANK repeat	550..582	CDD:293786	8/84 (10%)
		ANK repeat	585..618	CDD:293786	10/32 (31%)
		ANK repeat	620..651	CDD:293786	10/30 (33%)
		PHA02682	<902..>980	CDD:177464
		SH3_ASAP2	967..1022	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920