DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and smap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001120382.1	Gene:	smap1 / 100145457	XenbaseID:	XB-GENE-979112	Length:	471	Species:	Xenopus tropicalis

Alignment Length:	355	Identity:	87/355 - (24%)
Similarity:	139/355 - (39%)	Gaps:	101/355 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 THHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRS 425
            :...:.|..|..:.::.::       .|:...|.||.||.:..|||||.|||:.:||.|:|:||:
Frog     5 SEREKAQKQNEQHQAILSR-------MLREEDNKYCADCEAKGPRWASWNLGVFICIRCAGIHRN 62

  Fly   426 LGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAK 490
            ||||.|:|:|:.||.|..|.::.|.::||....::|||.:.::....:..:..|..:|:.:.:.|
Frog    63 LGVHISRVKSVNLDQWTPEQMQCMQDMGNTKARQMYEANLPENFRRPQTDQSVEFFIRDKYERKK 127

  Fly   491 YVERRFVCGMPKPQELLASETAEVLSI-DSGGVVEDGESGGS--GIAKRATLSLGGTRKWAVKKL 552
            |.::                .|.|..| .|...|:...|..|  ..|:::.|     .|...:|.
Frog   128 YYDK----------------NATVPGITSSSDAVQPSASSPSLQSAAEKSKL-----EKEKDRKK 171

  Fly   553 RRRQKQRSIPKTLS---------------------------------DDP---SIYN-----TAK 576
            ..|:|:|...|:|.                                 |.|   |:.|     .|.
Frog   172 EERKKEREPEKSLKPVGADKVLKKELPLEVKASPKKSPELTVDLLGLDAPAETSVSNGNTSTIAG 236

  Fly   577 TGDELE---------------DDDDDESINIPSMSLSISRDDLLVIGDD-----------LALDR 615
            ..|:|:               ....|.|.|..|.|:|.|..||.:..|.           |:.|.
Frog   237 VNDDLDIFGPMVSNPIPVSAAPPTQDTSTNPASTSISSSSGDLDLFTDQTTKSEETQKKPLSKDS 301

  Fly   616 -LETPGILGSDQESTDGESDAESPEELPFS 644
             |...|.....|::|.|.....||  :|:|
Frog   302 ILSLYGTTNMQQQNTTGMFMGPSP--MPYS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287
		PH	259..352	CDD:278594
		PH_ACAP	260..355	CDD:270070
		ArfGap	384..497	CDD:279720	41/112 (37%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
smap1	NP_001120382.1	ArfGap_SMAP	21..123	CDD:350068	39/108 (36%)
smap1	NP_001120382.1	Med15	<312..>454	CDD:312941	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910