DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and acap3

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_012821390.1	Gene:	acap3 / 100127680	XenbaseID:	XB-GENE-1013301	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	912	Identity:	338/912 - (37%)
Similarity:	495/912 - (54%)	Gaps:	143/912 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            |::||||:|||||||..:.:.|:|:..:|.:|:|::|||:..:::||.|:.....|...:.||.|
Frog     2 TVDFEECIKDSPRFRAAIDEVETDVVEIEAKLDKLVKLCSSMLEAGKTYLTTNKHFVSGIRDLSQ 66

  Fly    69 HFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEG 133
            ....::.....|.|.....|||..:|.||.|||.|:|.:.|.:|||||:.:.|:.|..|.||.|.
Frog    67 QCKKDEMISECLDKFGDSLQEMVNYHMILFDQAQRSVRQQLHMFVKDDVRKFKESKKQFDKVRED 131

  Fly   134 YDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQA 198
            .|.||:|||||.:::|.|::||::.|:.::.||:|.|||||..|.:.||:|...||..:|.:..|
Frog   132 LDIALVKNAQAPRHKPHEVEEASSTLTITRKCFRHLALDYVLQINVLQAKKKFEILDAMLSFMHA 196

  Fly   199 CVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR--------YCDS---- 251
            ..|::.||:.|.|:.:.:.|.::.:|:.|..|....::.|:::|.::.:        |.||
Frog   197 QYTFFQQGYSLLNELNPYMKQLASELDQLVIDSAVEKREMEHKHATIQQRTLLQDFSYDDSKADF 261

  Fly   252 NTNSTSNKI-EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNE 315
            |.::.:..: ||||||:.|..||||.||||.:.::||||:|:. :|..:|:.||||:|:|:|..:
Frog   262 NVDAPNGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKL-KDVLTVVVEDLRLCTVKPCED 325

  Fly   316 GDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQH--DSTHHSRPQSTNAPNNSL-- 376
            .:|||||||:||:||.:|||||..:...||.|:|.||.:|.:.  |:.:..|...|.:|:.|.
Frog   326 IERRFCFEVVSPSKSCMLQADSEKLRQSWIQAVQASIASAYRETPDNYYIERLDRTASPSTSSID 390

  Fly   377 ----PAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKV 433
                ..:|.:..|..|:    |.||..||||...:||||||||||||||||||:|||||||:|||
Frog   391 SASDSRERSVKGESILQRVQSIAGNDQCCDCGQTDPRWASINLGITLCIECSGIHRSLGVHFSKV 455

  Fly   434 RSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVC 498
            ||||||:||.|.:|:|.||||..:|:||||:. :..||||||..|....:|.||||||||::|:
Frog   456 RSLTLDSWEPELLKLMCELGNSTINQIYEAKC-EHLGLKKPTSGCSRQDKEIWIKAKYVEKKFL- 518

  Fly   499 GMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRSIPK 563
                 :.|.|.|            ||:...               .::|:|||..|......:|.
Frog   519 -----KRLGAVE------------VENDRK---------------PQRWSVKKCHRNNSTTKVPS 551

  Fly   564 TL--------SDDPSIYNTAKT------------GDELED-------DDDDESIN---------- 591
            |.        |..|::.::|.|            .|||:.       .....|:|
Frog   552 TRRKYRHEMGSASPAMLSSAATLERKFRRDSLFCPDELDSLFSYFDTGSGPRSVNPLPAQHPLPA 616

  Fly   592 -----------------IPSMSLSI---------SRDDLLVIG---DDLALDRLETPGILGSDQE 627
                             :|...||.         ..:|:||.|   |.:..:..|.       .|
Frog   617 VPWTGSGAEPGGSAMPFLPDGGLSSDSGLGGSTDGSNDILVFGAVVDSVTEEECEV-------SE 674

  Fly   628 STDGESDAE----SPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLH 688
            .:.||.:.|    .||:|  .:|....|::.||...|||||..|.|.||:..|.|.:|..::.|.
Frog   675 DSSGEVETEQEPSDPEDL--RELHPGLLMFRASRTRNLPVMAEALANGANVNWVNDEDESKTPLI 737

  Fly   689 QAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKAL 753
            ||||.||::||||||.|||.::..|..|.:.:|.:|..||..||.|.||..|.......||:..|
Frog   738 QAVIGGSLIACEFLLQNGADVNQTDMRGRAPIHHATYLGHTGQVCLFLKRGANQHAVDEDGQDPL 802

  Fly   754 DIAVDQENADIVTLLRLTQLNDEIGPNDEYNGE--DETYKNVMKDFSKLPASQTRVLRQR--HDS 814
            .|||...||||||||||.::|:|:...:...|:  |.||.::.::||.:.::....|.:|  |.|
Frog   803 SIAVQAANADIVTLLRLARMNEEMREAEGPFGQPGDTTYLDIFREFSHMASNNPEKLSRRSVHFS 867

  Fly   815 NT 816
            |:
Frog   868 NS 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	75/198 (38%)
		PH	259..352	CDD:278594	49/93 (53%)
		PH_ACAP	260..355	CDD:270070	51/95 (54%)
		ArfGap	384..497	CDD:279720	73/116 (63%)
		ANK	652..768	CDD:238125	54/115 (47%)
		Ank_4	683..736	CDD:290365	25/52 (48%)
		ANK repeat	687..713	CDD:293786	16/25 (64%)
		ANK repeat	715..746	CDD:293786	11/30 (37%)
acap3	XP_012821390.1	BAR_ACAP3	16..215	CDD:153321	75/198 (38%)
		PH_ACAP	271..367	CDD:270070	52/96 (54%)
		ArfGap_ACAP3	403..518	CDD:350075	73/115 (63%)
		ANKYR	<689..818	CDD:223738	60/130 (46%)
		ANK repeat	729..762	CDD:293786	17/32 (53%)
		ANK repeat	764..795	CDD:293786	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1120
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm48128
Panther	1	1.100	-	-	LDO	PTHR23180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R258
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110