DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and acap2b

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001096109.1	Gene:	acap2b / 100124613	ZFINID:	ZDB-GENE-050208-640	Length:	264	Species:	Danio rerio

Alignment Length:	275	Identity:	97/275 - (35%)
Similarity:	159/275 - (57%)	Gaps:	16/275 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |:.|::||||||||||||..:.:.|.|:..||.:|:|::|||...:|:||.|......|...:.:
Zfish     1 MKITVDFEECLKDSPRFRATIEEVEGDVCELESKLDKLVKLCIGMIDAGKAYNTANKQFVSGIRE 65

  Fly    66 LQQHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKV 130
            |.|....:....::|.......|||..:||||.|||.|::...|..|:::|:.:.|:.|..|.||
Zfish    66 LAQQSATDDVIESSLSTFAENLQEMINYHTILFDQAQRSIKSQLQTFIREDLRKFKEAKKQFDKV 130

  Fly   131 SEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDY 195
            ||..:.||.|||||.:|:..|::||:|||:|::.||:|..||||..|.:.|:::...||.::|.:
Zfish   131 SEEKEAALSKNAQAPRNKAHEVEEASNILNATRKCFRHIVLDYVLQINVLQSKRRSEILKSMLSF 195

  Fly   196 YQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNRYCDSNTNSTSNKI 260
            ..|.:|::|||:||.::.....|.::..|:.|..|..:..|.|:.:|.::.:           |:
Zfish   196 MYAHLTFFHQGYDLFSELQPLMKQLTGQLDQLVLDATKERKDMETKHSTIQQ-----------KV 249

  Fly   261 EGYLFKKKSKGFKTW 275
            :.:|     :|...|
Zfish   250 KDFL-----RGVNFW 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	73/198 (37%)
		PH	259..352	CDD:278594	4/17 (24%)
		PH_ACAP	260..355	CDD:270070	3/16 (19%)
		ArfGap	384..497	CDD:279720
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
acap2b	NP_001096109.1	BAR	18..217	CDD:299863	73/198 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3448
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1149
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm24348
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980