DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and asap1

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_031759002.1	Gene:	asap1 / 100036721	XenbaseID:	XB-GENE-1013472	Length:	1136	Species:	Xenopus tropicalis

Alignment Length:	880	Identity:	193/880 - (21%)
Similarity:	324/880 - (36%)	Gaps:	230/880 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DSPRFRQFVSKEES---DIEHLEQ-------RLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQ 67
            :||....|.::.:|   .|..||:       .|:|:.|......:||:::|:|:..:|.:|....
Frog    39 NSPTTSSFTTRLQSCRNSINVLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQALDKFG 103

  Fly    68 QHFL--DNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVK-DYKGHFLK 129
            .:||  ||.:...|..|.....:|::.....||...|..|:..|...:|.|:..|| |.|..|.:
Frog   104 SNFLSRDNADLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDR 168

  Fly   130 VSEGYDNALIKNAQASKNRPQEM---------QEAANILSASKSCFQHTALDYVNYITLAQARKV 185
            ..:.|:....|..:..:...::.         .|.|..:...:..||....:|:..:...:.:|.
Frog   169 AWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKG 233

  Fly   186 PSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDL----------------------NALR 228
            ..:|..|:.||.|...::..|....:...::.:.::.||                      ::|:
Frog   234 VDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQ 298

  Fly   229 GDYQQLEKAMQNRHMSVNRYCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQL-VYRKR 292
            .|.::..:..|::....:.:.........::.:|||.||.....|.|.||...:.:..| :....
Frog   299 LDQKESRRDSQSKQAGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCTVKNGILTISHAT 363

  Fly   293 SNEDSFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHS----IG 353
            ||.....:   :|..|.|:|  ..|.:.||::||..:::..||:.......|||.|.:|    :.
Frog   364 SNRPPTKL---NLLTCQVKP--NADEKKCFDLISHNRTYHFQAEDEQEYIAWISVLTNSKEDALN 423

  Fly   354 AAIQHDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIE 418
            .|.:.|       |||.  .:||....:...::..|.|||..||||.||:|.|.|.||||..|||
Frog   424 MAFRGD-------QSTG--ESSLEDLTKAIIDDVQKTPGNEVCCDCGSPDPTWLSTNLGILTCIE 479

  Fly   419 CSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVR 483
            |||:||.:|||.|:::||.||...:..:.:...:||...|.|.|..:.....  ||:...::..|
Frog   480 CSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEGNLLSPSA--KPSPSSDMIAR 542

  Fly   484 EAWIKAKYVERRF---VC--GMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGG 543
            :.:|.||||||||   :|  |..|..|||.
Frog   543 KEYITAKYVERRFSRKICSTGAEKLNELLE----------------------------------- 572

  Fly   544 TRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIG 608
                |||                                                 |||.|.:|
Frog   573 ----AVK-------------------------------------------------SRDLLALI- 583

  Fly   609 DDLALDRLETPGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGAD 673
                                   :..||..|.:                               :
Frog   584 -----------------------QVYAEGVEIM-------------------------------E 594

  Fly   674 KMWKNPQDRQRSFLHQAVISG---SVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLL 735
            .:.::.|:...:.||.||.:.   |:...:||:.|...:|.....|.:|||..........:.||
Frog   595 PLLESGQEPGETALHYAVRTADHTSLPLVDFLVQNCGNLDKQTGKGNTALHYCCLYNKPECLKLL 659

  Fly   736 LKHKAAYDLSSSDGKKALDIAVDQENA---DIVTLLRLTQLNDEIGPNDEYNGEDETYKNVMKDF 797
            |:.|...|..:..|:.|.|:|..|:.|   ::|:.....:||..:....::|...|.......|.
Frog   660 LRGKPTIDAVNHIGETAFDVAKRQKAAQCEELVSQALAGKLNPHVHVEYDWNLRQEEMDESDDDL 724

  Fly   798 SKLPASQTRVLRQR--------HDSNTLESQRSSL 824
            ...|:.   :.::|        |.|:.....:.||
Frog   725 EDKPSP---IKKERSPRPQSFCHSSSISPQDKLSL 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	47/220 (21%)
		PH	259..352	CDD:278594	28/97 (29%)
		PH_ACAP	260..355	CDD:270070	28/99 (28%)
		ArfGap	384..497	CDD:279720	50/115 (43%)
		ANK	652..768	CDD:238125	26/121 (21%)
		Ank_4	683..736	CDD:290365	14/55 (25%)
		ANK repeat	687..713	CDD:293786	9/28 (32%)
		ANK repeat	715..746	CDD:293786	9/30 (30%)
asap1	XP_031759002.1	BAR_ASAP1	54..268	CDD:153325	45/213 (21%)
		PH_ASAP	319..425	CDD:270071	28/110 (25%)
		ArfGap_ASAP1	440..561	CDD:350073	50/122 (41%)
		Ank_2	585..660	CDD:403870	18/105 (17%)
		ANK repeat	604..637	CDD:293786	9/32 (28%)
		ANK repeat	639..670	CDD:293786	9/30 (30%)
		PHA03247	<735..1052	CDD:223021	5/22 (23%)
		SH3_ASAP1	1078..1134	CDD:212898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D751525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920