DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and acap3b

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001076484.1	Gene:	acap3b / 100009646	ZFINID:	ZDB-GENE-070209-274	Length:	846	Species:	Danio rerio

Alignment Length:	884	Identity:	334/884 - (37%)
Similarity:	483/884 - (54%)	Gaps:	115/884 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQ 68
            |::||||:|||||||..:.:.|:|:..:|.:|:|::|||:..:::|:.|......|...:.||..
Zfish     2 TVDFEECIKDSPRFRANIDEVETDVVEIEAKLDKLVKLCSGMIEAGRAYATANKLFVNGIRDLSH 66

  Fly    69 HFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSEG 133
            |....:.....|.|.....||:..:|.||.|||.|:|.:.|..|||:|:.:.|:.|..|.||.|.
Zfish    67 HCKKEEMISECLEKCGESLQEIVNYHMILFDQAQRSVKQQLHSFVKEDVRKFKETKKQFDKVRED 131

  Fly   134 YDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSILSTLLDYYQA 198
            .:.|.:|||||.:|:|.|::||.:.|..::.||:|.|||||..|.:.||:|...||.::|.:.||
Zfish   132 MEIAQVKNAQAPRNKPHEVEEATSTLITTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMQA 196

  Fly   199 CVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR--------YCDS---- 251
            ....:||||:|.::.|.:.|.::.:|:.|..|....::.|:::|.::.:        |.||
Zfish   197 QYGLFHQGFNLLDEIDPYMKKLAAELDQLVIDSAMEKREMEHKHATIQQRTLMQDFAYDDSKVEF 261

  Fly   252 NTNSTSNKI-EGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICSVRPVNE 315
            |.::.:..: ||||||:.|..||||.||||.:.::||||:||. :|:.:|:.||||:|||:|..:
Zfish   262 NVDAPNGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKRL-KDALTVVVEDLRLCSVKPCED 325

  Fly   316 GDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHH--------SRPQSTNAP 372
            .:|||||||:|||||.:|||:|..:...||.|:|.||.:|.:..|.::        :.|.:::..
Zfish   326 IERRFCFEVVSPTKSCMLQAESEKLRQAWIQAVQASIASAYREISENYYIERLDRTASPSTSSID 390

  Fly   373 NNSLPAKRRIHWEEFLK----IPGNAYCCDCRSPEPRWASINLGITLCIECSGVHRSLGVHYSKV 433
            :.|.|.:|.:..:..|:    :|||..||||...:||||||||||.|||||||:|||||||.|||
Zfish   391 SASEPRERVVRGDSILQRVQCLPGNEICCDCGQSDPRWASINLGILLCIECSGIHRSLGVHCSKV 455

  Fly   434 RSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRF-- 496
            ||||||.||.|.:|:|.||||.|:|:|||... ::.|||||........:|||||||||||:|
Zfish   456 RSLTLDTWEPELMKLMCELGNTVINQIYEGAC-EEQGLKKPGPNSSRQEKEAWIKAKYVERKFLK 519

  Fly   497 -VCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLRRRQKQRS 560
             :||                   |..::|.|..               :..|:|||.||......
Zfish   520 KMCG-------------------SEALLEGGRK---------------SHHWSVKKCRRHNSSIR 550

  Fly   561 IPKT---LSDDPSIYNTAKTG----------DELEDDDDDESI-------NIPSMSLSISRD--- 602
            .|||   ...|.:|.:.....          :.|...|:.:|:       :.|.....:|.|
Zfish   551 APKTRRKYRHDAAIMSPGNLSAAAAAAKFRRESLFCPDELDSLFSYFDTGSGPRSPAGLSSDSGL 615

  Fly   603 --------DLLVIGDDLALDRLETPGILGSDQES--TDGESDAESPEELPFSQLDANQLLYMASV 657
                    |:||.|.  .:|.:.......||:.|  .|.|.:|..||:  ..:||.|.||:.||.
Zfish   616 GGSTDGSTDILVFGS--VVDSVTEEECEDSDESSGEVDIEQEASDPED--GRELDPNTLLHKASR 676

  Fly   658 VHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHI 722
            ..|:|||..|.|.|||....:.:|..:|.|.|||..||::||||||.|||.::..|..|...||.
Zfish   677 ARNMPVMAEALAHGADVNSVSEEDESKSPLIQAVTGGSLIACEFLLQNGADVNQRDIRGRGPLHH 741

  Fly   723 STAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGED 787
            :|..||..||.|.||..|.......||:..|.|||...||||||||||.::|:|:...|...|:.
Zfish   742 ATCLGHTGQVCLFLKRGAGQMEVDEDGQDPLSIAVQAANADIVTLLRLARMNEEMREADGPLGQP 806

  Fly   788 ETYKNVMKDFSKLPASQTRVLRQRHDSNTLESQRSSLTN 826
            :         :.:|.|..||.|:     :|.:...||::
Zfish   807 D---------ASVPVSPLRVKRK-----SLRASPRSLSS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	73/198 (37%)
		PH	259..352	CDD:278594	51/93 (55%)
		PH_ACAP	260..355	CDD:270070	53/95 (56%)
		ArfGap	384..497	CDD:279720	72/119 (61%)
		ANK	652..768	CDD:238125	54/115 (47%)
		Ank_4	683..736	CDD:290365	26/52 (50%)
		ANK repeat	687..713	CDD:293786	15/25 (60%)
		ANK repeat	715..746	CDD:293786	12/30 (40%)
acap3b	NP_001076484.1	BAR_ACAP3	16..215	CDD:153321	73/198 (37%)
		PH	269..363	CDD:278594	52/94 (55%)
		PH_ACAP	271..367	CDD:270070	54/96 (56%)
		ArfGap	403..520	CDD:279720	72/117 (62%)
		ANK repeat	666..697	CDD:293786	15/30 (50%)
		ANK	668..787	CDD:238125	56/118 (47%)
		Ank_2	671..759	CDD:289560	41/87 (47%)
		ANK repeat	699..732	CDD:293786	17/32 (53%)
		ANK repeat	734..759	CDD:293786	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3448
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1149
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	1	1.000	-	-		otm24348
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	LDO	PTHR23180
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980