DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and LOC100005008

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_001344168.4	Gene:	LOC100005008 / 100005008	-ID:	-	Length:	958	Species:	Danio rerio

Alignment Length:	720	Identity:	149/720 - (20%)
Similarity:	255/720 - (35%)	Gaps:	188/720 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EESDIEH--------------------LE-QRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQ 67
            :|:||:|                    |: :..|.::...::::.||......:||.:    |..
Zfish    53 QETDIQHEASVDGSSHQSTSASVPPDLLDVKSSETLVWPSSISISSGLSVEALRSADS----DDS 113

  Fly    68 QHFLDNKNAHNALGKLIHCFQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGHFLKVSE 132
            ....|:...|..|.|..|..|:.:|     .|:.:.....|..:.::.:
Zfish   114 PAASDSPKTHQHLSKGQHNVQKASK-----TDKLTDVQWANEEIHLQSE---------------- 157

  Fly   133 GYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYV-NYITLAQARKVPSILSTLLDYY 196
                    :.|...:||::.:.|...:|..|........|.. :..|::|        |:.||.:
Zfish   158 --------SLQKMPDRPKKPRAATIRVSRKKQTLSGQKSDQTRSEFTVSQ--------SSWLDVW 206

  Fly   197 QA-------------CVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMS---- 244
            :.             .::.:.:..|   .|.|:..:::...|..:.::.:....:|.:|..
Zfish   207 KGRKHMVLWATLDGNLMSMWKKRTD---KFTEYVFHVASVTNISKQEHGRFSIHLQKKHFEFMAH 268

  Fly   245 --------VNRYCDSNTNS--TSNKIEGYLFKK--KSKGFKTWCRR--WFYLSDNQLVYRKRSNE 295
                    ::...||....  .:.|..|.|..|  :.|.:...|..  |.|          .|.|
Zfish   269 NAAVQDGWLHSLYDSRGREAIAAPKKHGPLSMKDRRKKVYSAICGHSLWIY----------SSKE 323

  Fly   296 D---SFSVMEEDLRICSVRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQ 357
            |   ...:|...:.|.||:...    |:.|.:|:|.::....|||:...|.|:.:|...|
Zfish   324 DFNLGLGMMCVSMNIASVKSTG----RYGFSLITPYRTFNFSADSSKEASAWLESLNDVI----- 379

  Fly   358 HDSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLCIECSGV 422
                       .||.:.|..|.|.  |..    |.|..|.||.:..|.|||:||.:.:|..|:|.
Zfish   380 -----------RNALSYSEVALRL--WSS----PCNKVCADCGAANPEWASVNLLVVICEACAGA 427

  Fly   423 HRSLGVHYSKVRSLTLD--AWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQ----CEIG 481
            |||:|...||||.|.||  .|....:::.:..||:..|.::...|       .||||    ....
Zfish   428 HRSMGSSRSKVRGLKLDDKVWTEPLIQLFVLHGNKTANNVWGHNI-------PPTEQISPLASPD 485

  Fly   482 VREAWIKAKYVERRFVCGMP--KPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGT 544
            .|..:|.|||.:..:....|  ..|:||.....||:   .|..||:..|.....||.:..|....
Zfish   486 QRAEFILAKYHKGLYRKAHPLAASQKLLDQRLREVV---CGPAVEETVSLLCSGAKVSCSSSDPE 547

  Fly   545 RKWAV-----------KKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLS 598
            .|.|:           .:|.|..:....|    |.....::.:..:||....|:|.......:.|
Zfish   548 LKSAIAVAESAGQALQTELLRHNEFVEAP----DFEQTRHSEEQMEELHGKLDEERFLFSQENQS 608

  Fly   599 ISRDDLLVIGDDLALDRLETPGILGSDQESTDGESD----AESPEELPFSQLDANQLLYMASVVH 659
            .:.|         .||..|...:.    :.:|||:.    :...:.|..|..:.|.||  :.:.|
Zfish   609 AAYD---------VLDLTEVVSVF----DCSDGETHQFEVSTLTDRLTCSADERNALL--SHMTH 658

  Fly   660 NLPVM 664
            .:.|:
Zfish   659 IMKVV 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	35/227 (15%)
		PH	259..352	CDD:278594	25/99 (25%)
		PH_ACAP	260..355	CDD:270070	25/101 (25%)
		ArfGap	384..497	CDD:279720	40/118 (34%)
		ANK	652..768	CDD:238125	3/13 (23%)
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
LOC100005008	XP_001344168.4	PH-like	291..375	CDD:302622	24/97 (25%)
		PH	292..380	CDD:278594	26/117 (22%)
		ArfGap	386..503	CDD:279720	43/129 (33%)
		RhoGAP	769..939	CDD:295372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900