DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CenB1A and zgc:162872

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_009290262.1	Gene:	zgc:162872 / 100004931	ZFINID:	ZDB-GENE-081022-1	Length:	701	Species:	Danio rerio

Alignment Length:	846	Identity:	272/846 - (32%)
Similarity:	416/846 - (49%)	Gaps:	197/846 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWD 65
            |...::||:|::|||.|||.:.|.|||:..||.|:||::|||...||:|:.|......|..:|.:
Zfish     1 MDTFLDFEDCIRDSPAFRQSLDKCESDMSELESRVEKVMKLCGQMVDAGQNYTSCNQLFLCALSE 65

  Fly    66 LQQHFLDNKNAHNALGKLIHC-------FQEMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDY 123
            ...:       |.:.|.:::|       .|||.:|.|:|.||..|.:.:.|:..:...:.|:::.
Zfish    66 FTAY-------HKSDGVILNCLRQFNQGLQEMIQFQTMLFDQTQRAISQQLTNLLSQFVPQIRET 123

  Fly   124 KGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDYVNYITLAQARKVPSI 188
            :..|:::.:..|:|::||||.|:::|.:.:.|.::|.|::.|:||.||||...:...:.::...|
Zfish   124 RREFVRIGDDLDSAVVKNAQVSRHKPVDAERATHLLLATRKCYQHFALDYCLQLNNFKVQQKLDI 188

  Fly   189 LSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQLEKAMQNRHMSVNR------ 247
            |:::..|:.|..|::||||||..|.:...|.::..|:.|..|.....|.::|.|:.|.:
Zfish   189 LNSVFSYFHAQYTFFHQGFDLLRDLEPTMKTMASQLSQLSTDCSAKRKDLENTHLLVQQRDASGE 253

  Fly   248 ---YCDSNTNSTSNKIEGYLFKKKSKGFKTWCRRWFYLSDNQLVYRKRSNEDSFSVMEEDLRICS 309
               .|:.:...|   |:|||||:..|..|||.|.||...:|||:|.| |:::...|:.:|||:|:
Zfish   254 AVIVCNPSDGGT---IQGYLFKRSRKKNKTWKRCWFSTENNQLIYLK-SHKEQPVVLFDDLRLCA 314

  Fly   310 VRPVNEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQHDSTHHSRPQSTNAPNN 374
            |:.::..|||||||::|..|..:|||||.::.|.|::|:|..|..|.:...|    .|:|....:
Zfish   315 VKSLDVIDRRFCFELLSVQKCCVLQADSEELKSAWMNAVQGCIDMAYRDQVT----DQNTQVKES 375

  Fly   375 SLPAKRRIHWEEFLKIP----------------GNAYCCDCRSPEPRWASINLGITLCIECSGVH 423
            |.|          :.||                ||.:||||...||||||:|||||:||||||:|
Zfish   376 SAP----------VSIPDPPSHPPALGVALSGRGNQHCCDCGEAEPRWASVNLGITMCIECSGIH 430

  Fly   424 RSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIK 488
            ||||||.|||||||||:||.|.:|::..|||||:|.|||....|  ||:||:.......:|.||:
Zfish   431 RSLGVHLSKVRSLTLDSWEPEQLKLLCVLGNEVINGIYEREAAD--GLQKPSAGSPRQDKEQWIR 493

  Fly   489 AKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRATLSLGGTRKWAVKKLR 553
            :||||:|||.      ..|....|:.|                                   |||
Zfish   494 SKYVEKRFVA------RHLDGPDADAL-----------------------------------KLR 517

  Fly   554 RRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLET 618
            .|::
Zfish   518 ARKR------------------------------------------------------------- 521

  Fly   619 PGILGSDQESTDGESDAESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKNPQDRQ 683
                                             ||.|||..:|..|..:.|.||:..|.|.:...
Zfish   522 ---------------------------------LYSASVSGDLVAMAESLAEGAEINWNNNEQEG 553

  Fly   684 RSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSD 748
            |:.|..:.|.||::||||||.|||.::..|:.|..|||.:...||..||.||||..|....:...
Zfish   554 RTALIGSAIGGSLLACEFLLQNGANVNHRDQRGQGALHAAATYGHTGQVCLLLKRGANQYAADEK 618

  Fly   749 GKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEY---NGEDETYKNVMKDFSKLPASQTRVLRQ 810
            |...|.||::..:||||||||:.::|:|:..::.:   .|:|||::::.:|||.:.:.....|.:
Zfish   619 GNDPLSIAIETAHADIVTLLRMARMNEEMRDSEGFFGSVGDDETFQDIFRDFSNMASHDPEKLTR 683

  Fly   811 R 811
            |
Zfish   684 R 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	65/205 (32%)
		PH	259..352	CDD:278594	43/92 (47%)
		PH_ACAP	260..355	CDD:270070	44/94 (47%)
		ArfGap	384..497	CDD:279720	67/128 (52%)
		ANK	652..768	CDD:238125	49/115 (43%)
		Ank_4	683..736	CDD:290365	24/52 (46%)
		ANK repeat	687..713	CDD:293786	13/25 (52%)
		ANK repeat	715..746	CDD:293786	13/30 (43%)
zgc:162872	XP_009290262.1	BAR_ACAPs	18..217	CDD:153287	65/205 (32%)
		PH	265..357	CDD:278594	44/95 (46%)
		PH_ACAP	266..362	CDD:270070	45/96 (47%)
		ArfGap	399..504	CDD:279720	67/112 (60%)
		Ank_2	<508..583	CDD:289560	32/203 (16%)
		ANK	522..638	CDD:238125	49/115 (43%)
		ANK repeat	552..583	CDD:293786	14/30 (47%)
		Ank_2	557..649	CDD:289560	41/91 (45%)
		ANK repeat	585..616	CDD:293786	13/30 (43%)
		ANK repeat	618..649	CDD:293786	14/30 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3448
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55583
OrthoDB	1	1.010	-	-		D124295at33208
OrthoFinder	1	1.000	-	-		FOG0000653
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101039
Panther	1	1.100	-	-	O	PTHR23180
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.790