DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CenB1A and appl2

DIOPT Version :9

Sequence 1:	NP_524458.1	Gene:	CenB1A / 42735	FlyBaseID:	FBgn0039056	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001121547.1	Gene:	appl2 / 100000135	ZFINID:	ZDB-GENE-081016-2	Length:	662	Species:	Danio rerio

Alignment Length:	466	Identity:	103/466 - (22%)
Similarity:	185/466 - (39%)	Gaps:	77/466 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHFLD 72
            ||.|:|||:.|..:|..|.|...|.....::::       |.:.....|:..|::...|.:..|:
Zfish    11 EEALQDSPQTRSLLSVFEEDAGTLTNYTNQLLQ-------SMQRVFGAQNEMALATEQLSKQLLE 68

  Fly    73 NKNAHNALGK----LIHCFQ-------EMNKFHTILLDQASRTVLKNLSVFVKDDINQVKDYKGH 126
            .:..:.||.|    :|:..|       |:|..|:.|..|.:..::..:..|.:.|:.::...|..
Zfish    69 YEKQNFALAKGDEEVINTLQQFAKSVEELNALHSELSTQIADKMVFPMVQFREKDLTEISTLKEI 133

  Fly   127 FLKVSEGYDNALIKNAQASKNRPQEMQEAANI--LSASKSCFQHTALDYVNYITLAQARKVPSIL 189
            |...::.::.|::|.::..|.|..|..:|..:  ::.|:......|:.|...:...|.||..::|
Zfish   134 FSIATDEHEAAMVKYSRLPKKRENEKVKAEVVREVAYSRRKQHQAAMQYYCALNALQYRKRVAML 198

  Fly   190 STLLDYYQACVTYYHQGFDLCN-DFDEFFKNISE-----------DLNALRGDYQQLEKAMQNRH 242
            ..:|.|..|.:.::.:|.:|.: ..|.|..::|.           |...:|...::|.....:.:
Zfish   199 EPMLGYTHAQINFFKKGMELVSKKLDSFLNSVSNMNESIESQLEIDAEVMRSSQRELLSVDDSVY 263

  Fly   243 MSVNRYCDSNTNSTSNKI---EGYLFKKKSKGFKT--WCRRWFYLSDNQLVYRKRSNEDSFSVME 302
            |.     |.:..:.|..:   .|||..:...|..|  |.|.:|:.....|:.:.|.......|:
Zfish   264 MP-----DHDQAAVSRALIQKAGYLNIRNKTGLVTTAWDRLFFFTQGGNLMCQPRGAVAGGMVL- 322

  Fly   303 EDLRICSVRPVNEGDRRFCFEVISPT--KSHILQADSADMLSLWISALQ---------------- 349
             ||...||..|:..|||:||::.||.  .|.||||:|......||..|.
Zfish   323 -DLDNSSVMAVDCEDRRYCFQITSPNGKTSLILQAESKREYEEWICTLNNISRQIYLTDNPEAVA 386

  Fly   350 ---HSIG-AAIQHDSTHHSRPQSTNAPNNSLPA----------KRRIHWE-EFLKIPGNAYCCDC 399
               |... .|:...::...|.:.:..|:.:.|.          |..:..| |.|.:||.....|.
Zfish   387 IKLHQTALQAVTPITSFEKRAEGSPNPDRAKPGGLPVTSQEAEKSSVSLEPEDLIVPGTPIQFDI 451

  Fly   400 RSPEPRWASIN 410
            ..|...:...|
Zfish   452 MLPASEFLDQN 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CenB1A	NP_524458.1	BAR_ACAPs	18..217	CDD:153287	43/212 (20%)
		PH	259..352	CDD:278594	33/118 (28%)
		PH_ACAP	260..355	CDD:270070	33/121 (27%)
		ArfGap	384..497	CDD:279720	8/28 (29%)
		ANK	652..768	CDD:238125
		Ank_4	683..736	CDD:290365
		ANK repeat	687..713	CDD:293786
		ANK repeat	715..746	CDD:293786
appl2	NP_001121547.1	BAR	21..235	CDD:299863	45/220 (20%)
		BAR-PH_APPL	253..375	CDD:270067	36/128 (28%)
		PH	277..377	CDD:278594	32/101 (32%)
		PTB_APPL	488..614	CDD:269980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900