DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and RASSF2

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_011527712.1	Gene:	RASSF2 / 9770	HGNCID:	9883	Length:	328	Species:	Homo sapiens

Alignment Length:	274	Identity:	87/274 - (31%)
Similarity:	148/274 - (54%)	Gaps:	36/274 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 QRYIQIQMDCYPKENVAAASEGESSRADAPSITSGAAAGDEL--------------TQTEDLYTA 600
            :|.|::||            :.::.|...|..:|...:|..|              .|..::...
Human    63 RRPIRLQM------------QDDNERIRPPPSSSSWHSGCNLGAQGTTLKPLTVPKVQISEVDAP 115

  Fly   601 SEGVDGPDGDG--SAGLH-VTEDGVVLRRPPRTGASAIKRRSGNRRSRTKLKR----RCSINGHY 658
            .||...|...|  |.||. :.||...|.   ||.:....||.||.|:.:..:|    |.|||||:
Human   116 PEGDQMPSSTGTYSRGLKPLQEDTPQLM---RTRSDVGVRRRGNVRTPSDQRRIRRHRFSINGHF 177

  Fly   659 YNRETSFFTPPYGSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRLKDDEY 723
            ||.:||.|||.|||..:|.::|.:||.:|:.|:|.|:|:::|...|:|::|..:||:::||..:|
Human   178 YNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQKLKATDY 242

  Fly   724 PLITRVTLGPHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECRAILERYDQELAREVAKIKERY 788
            |||.|:..||.|.::::||::..:.:|::.:|||::...:|..::.:::..:|..|||.|:..:|
Human   243 PLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVKKLMRKY 307

  Fly   789 AELRRRIVSRMESL 802
            ..||..|..|:|.:
Human   308 TVLRLMIRQRLEEI 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	36/83 (43%)
		Nore1-SARAH	762..799	CDD:293125	10/36 (28%)
RASSF2	XP_011527712.1	rasfadin_RA	179..265	CDD:176379	36/85 (42%)
RASSF2	XP_011527712.1	Nore1-SARAH	279..318	CDD:293125	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157837
Domainoid	1	1.000	80	1.000	Domainoid score	I8603
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3848
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1043350at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41862
orthoMCL	1	0.900	-	-		OOG6_105083
Panther	1	1.100	-	-	LDO	PTHR22738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5365
SonicParanoid	1	1.000	-	-		X2208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790