DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rassf and mical2b

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_005174396.1	Gene:	mical2b / 569564	ZFINID:	ZDB-GENE-061207-15	Length:	1679	Species:	Danio rerio

Alignment Length:	873	Identity:	145/873 - (16%)
Similarity:	280/873 - (32%)	Gaps:	291/873 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CHKCGKPVYFAERKQSIGYDWHPECLRCEECGKRLNPGQHAEHKSVPYCHVPCYGALFGPQLFGH 68
            |..|.|.||..||..:.|:.:|.||.||..||..|..|.|.
Zfish  1013 CVFCQKRVYIMERLSAEGFFFHRECFRCHICGCSLRLGAHT------------------------ 1053

  Fly    69 GTRVESHKSYGVKGAQKPTGAQANGPPLPRDHLESKLKVYNQFYDNKSLEIRSREVNNRLVLEGA 133
                                                       :|::
Zfish  1054 -------------------------------------------FDSQ------------------ 1057

  Fly   134 LRVYWGVQGVIHLKEDDDQRILVRKRNSCRVSKAANESSSDKENEASESLAPPTTTTAEVDQLST 198
                   ||..:.|....||....:.....:......||       |.:::..|:|.....|.|
Zfish  1058 -------QGTFYCKMHFSQRKTSTRHRRGEIQDGGIRSS-------SITISNHTSTDGTRGQPS- 1107

  Fly   199 DVSLSESMTFDSCSLNEISELPTTPEDASANTTANSKEQT----NGNVCNDD--EDTTTTDSSGT 257
                  ...|||.:..::..||.:.|..|.:...:|.::.    :...|.|.  :....:.:.|.
Zfish  1108 ------GGEFDSSTQQDLQTLPDSKEIISVSEVKDSSKKADPADSAPACPDSPLQKVKRSTAKGE 1166

  Fly   258 LVEAPTASTSCVSSTLPSKL-DRLEKLDWDDIDDLLQVERRHNDKDRIYETMPVKLPSSQSSSDS 321
            :..........:.||||..| .:..:...:|..::|..|..::|.:.|:|::..|.||:.|
Zfish  1167 ITNKNILWKKKIRSTLPLVLMKKFHRGKPEDKTEVLAEEDGNSDFEEIHESLSSKKPSNPS---- 1227

  Fly   322 SPSKTSTETTTTTESSST-----------------QSASTNTSSTDDFMTATGSLTANTNTQNTT 369
                |.:....|.::|||                 :....::||.:..:|:..|...:.:.:...
Zfish  1228 ----TDSNCLPTKDNSSTPLDEIPKIPLYRTHVLPEYPKPSSSSPEPIVTSISSDPISFSPKKKL 1288

  Fly   370 TVSTTE-TSLDNFETCDDAT----------LKP----------------------IDFEDFKRSV 401
            |:|.:| ..|.|::..:...          :||                      ..|:.:..::
Zfish  1289 TLSLSEKEKLLNWDLTNPGKSGAEEQQQQHVKPSISLQHDHPEPTHPQPEPAPPLFGFQQWANNL 1353

  Fly   402 HQDYVNGANSFTEPNEGTLKRNQPIDPSRIHDSLKLYGENSAMSKSFNCEHALRSIDPTLINDTM 466
            .:.:..|:|..      .|:||:|:....:.:.            |||
Zfish  1354 RKSFSKGSNPV------VLRRNRPMKARPLSEG------------SFN----------------- 1383

  Fly   467 NLRSSVGSPHSAQRQYALQKSGSATVTSRDQKKPYQQGRQLFEKGINRSKSGPSCFVYSDSDDDD 531
                 ||:....:     ::.||.......:.:...:...|.|:....||:       |....||
Zfish  1384 -----VGAVFQDE-----ERCGSLVDEGEARPRTESEIASLLEQVALGSKT-------SRGTKDD 1431

  Fly   532 EATLRPQRM---ATIRRSDIPQRYIQIQMDCYPKENVAAASEGESSRADAPSITS----GAAAGD 589
            .|:|.|:::   :::|               ..:...|..|.||..: |..||.|    .|:|..
Zfish  1432 MASLPPRKLNFFSSLR---------------IKRVEGAEQSRGEGQK-DILSILSRFRNKASAQQ 1480

  Fly   590 ELTQTEDLYTASEGVDGPDGDGSAGLHVTEDGVVLRRPPRTGASAIKR-----------RSGNRR 643
            :..|..:  ::||....|....|..|...::.:.:|   :|.:..:||           .....:
Zfish  1481 QQQQKSN--SSSEDEQEPKLTHSGALQKKKEKIAIR---QTKSDELKRLHRAQVIQRQLEEVEEK 1540

  Fly   644 SRTKLKRRCSINGHYYNRETSFFTPPYGSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFI 708
            .|:..::..::............:....:.:..|          ..|||||.|:........:|
Zfish  1541 QRSLEEKGVALEKVLRGENGDDGSTDEAALLQTW----------FKLVLEKNKLSRYESELMIF- 1594

  Fly   709 VRDNGEQKRLKDDEYPLITRVTLGPHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECRAILERY 773
                .::..|:|.:..|        .:|:.|....:.  .::.::|:.:..|: |.|...::|:.
Zfish  1595 ----AQELELEDTQSRL--------QQDLRRRMATED--CEKSASELVEEQNI-LVEIMKVVEKR 1644

  Fly   774 DQELA-REVAKIKERY--AELRRRIVSR 798
            |:.:: .|..::||:.  .:|...|:||
Zfish  1645 DKLVSLLEEQRLKEKAEDRDLESLILSR 1672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785	18/52 (35%)
		UBQ	660..744	CDD:294102	13/83 (16%)
		Nore1-SARAH	762..799	CDD:293125	11/40 (28%)
mical2b	XP_005174396.1	FAD_binding_3	86..>274	CDD:332373
		CH	522..623	CDD:306753
		LIM_Mical	1013..1067	CDD:188823	22/145 (15%)
		Atrophin-1	1080..>1344	CDD:331285	49/285 (17%)
		YesN	<1308..1371	CDD:330857	8/68 (12%)
		DUF3585	1530..1665	CDD:314926	23/160 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900