DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and Rassf1

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001230677.1	Gene:	Rassf1 / 56289	MGIID:	1928386	Length:	340	Species:	Mus musculus

Alignment Length:	391	Identity:	89/391 - (22%)
Similarity:	149/391 - (38%)	Gaps:	113/391 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 SIDPTLINDTMNLRSSVGSPHSAQRQYALQKSGSATVTSRDQKKPYQQ---GRQLFEKGINRSKS 517
            |.:|.||    .||....|......:..|:::.:..:.....:.|.||   ||     |.....:
Mouse     2 SAEPELI----ELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQQHVPGR-----GHRFQPA 57

  Fly   518 GPSCFVYSDSDDDDEATLRPQRMATIRRSDIPQRYIQ----------IQMDCY-PKE-------- 563
            ||:...:.|...|        .:..:.|..:...:.:          :.:||. |::
Mouse    58 GPTTHTWCDLCGD--------FIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWDSALE 114

  Fly   564 ---NVAAASEGESSRADAPSITSGAAAGDELTQTEDLYTASEGVDGPDGDGSAGLHVT--EDG-- 621
               ||..|.|.|:               .:|:|.|    ..:.:...:|..::.|.::  :||
Mouse   115 RDTNVDEAVERET---------------PDLSQAE----TEQKIKDYNGQINSNLFMSLNKDGSY 160

  Fly   622 -----VVL-----------RRPPRTGASAIKRRSGNRRSRTKLKRRCSINGHYYNRETSFFTPPY 670
                 |.|           ::||    |....|.|..|| |.:|||           |||:.|.
Mouse   161 TGFIKVQLKLVRPVSVPSSKKPP----SLQDARRGTGRS-TAVKRR-----------TSFYLPK- 208

  Fly   671 GSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQ---KRLKDDEYPLITRVTLG 732
            .:...:.|.|.....|||..:|.|:.|...|..|:||...:...|   ::|.|||.||..|:..|
Mouse   209 DAIKHLHVLSRTRAREVIEALLRKFMVVDDPRKFALFERTERHGQVYLRKLSDDEQPLKLRLLAG 273

  Fly   733 PHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECR---AILERYDQELAREVAKIKERYAELRRR 794
            |.|. |..|::....:.|::.:.     .|:||..   .||:|.::|..|:   |.::|:..|::
Mouse   274 PSEK-ALSFVLKENDSGEVNWDA-----FSMPELHNFLRILQREEEEHLRQ---ILQKYSRCRQK 329

  Fly   795 I 795
            |
Mouse   330 I 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	29/86 (34%)
		Nore1-SARAH	762..799	CDD:293125	12/37 (32%)
Rassf1	NP_001230677.1	Mediates interaction with E4F1. /evidence=ECO:0000250	2..115		22/129 (17%)
		C1	52..101	CDD:237996	5/56 (9%)
		RA_RASSF1	130..286	CDD:340738	49/177 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..196		7/25 (28%)
		Nore1-SARAH	295..334	CDD:374597	12/44 (27%)
		MOAP1-binding. /evidence=ECO:0000250	311..314		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6693
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.690