DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and Rassf1

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001032644.1	Gene:	Rassf1 / 363140	RGDID:	1359383	Length:	340	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	87/391 - (22%)
Similarity:	149/391 - (38%)	Gaps:	113/391 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 SIDPTLINDTMNLRSSVGSPHSAQRQYALQKSGSATVTSRDQKKPYQQ---GRQLFEKGINRSKS 517
            |.:|.||    .||....|......:..|:::.:..:.....:.|.||   ||     |.....:
  Rat     2 SAEPELI----ELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQQHVPGR-----GHRFQPA 57

  Fly   518 GPSCFVYSDSDDDDEATLRPQRMATIRRSDIPQRYIQ----------IQMDCY-PKE-------- 563
            ||:...:.|...|        .:..:.|..:...:.:          :.:||. |::
  Rat    58 GPTTHTWCDLCGD--------FIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWDPALE 114

  Fly   564 ---NVAAASEGESSRADAPSITSGAAAGDELTQTEDLYTASEGVDGPDGDGSAGLHVT--EDG-- 621
               ||..|.|.|:               .:|:|.|    ..:.:...:|..::.|.::  :||
  Rat   115 RDTNVDEAVERET---------------PDLSQAE----TEQKIKDYNGQINSNLFMSLNKDGSY 160

  Fly   622 -----VVL-----------RRPPRTGASAIKRRSGNRRSRTKLKRRCSINGHYYNRETSFFTPPY 670
                 |.|           ::||    |....|.|..|| :.:|||           |||:.|.
  Rat   161 TGFIKVQLKLVRPVSVPSSKKPP----SLQDARRGTGRS-SAVKRR-----------TSFYLPK- 208

  Fly   671 GSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQ---KRLKDDEYPLITRVTLG 732
            .:...:.|.|.....|||..:|.|:.|...|..|:||...:...|   ::|.|:|.||..|:..|
  Rat   209 DAVKHLHVLSRTRAREVIEALLRKFMVVDDPRKFALFERTERHGQIYFRKLSDEEQPLKLRLLAG 273

  Fly   733 PHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECR---AILERYDQELAREVAKIKERYAELRRR 794
            |.|. |..|::....:.|::.:.     .|:||..   .||:|.::|..|:   |.::|:..|::
  Rat   274 PSEK-ALSFVLKENDSGEVNWDA-----FSMPELHNFLRILQREEEEHLRQ---ILQKYSRCRQK 329

  Fly   795 I 795
            |
  Rat   330 I 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	28/86 (33%)
		Nore1-SARAH	762..799	CDD:293125	12/37 (32%)
Rassf1	NP_001032644.1	C1_RASSF1	49..102	CDD:410435	9/65 (14%)
		RA_RASSF1	130..286	CDD:340738	47/177 (27%)
		Nore1-SARAH	296..334	CDD:406824	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740