DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and Rassf4

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001019446.1	Gene:	Rassf4 / 362423	RGDID:	1307785	Length:	322	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	107/390 - (27%)
Similarity:	173/390 - (44%)	Gaps:	95/390 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 PIDPSRIHDSLKLYGENSAMSKSFNCEHALRSID--------PTLINDTMNLRSSVGSPHSAQRQ 481
            ||..|:    ..|..|..::.|::||.|..||..        ..:|...:|:...:..|...|.|
  Rat    12 PISDSK----FILKSELLSLLKTYNCYHEGRSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQ 72

  Fly   482 YALQKSGSATVTSRDQKKPYQQGRQLFEKGINRSKSGPSCFVYSDSDDDDEATLRPQRMATIRRS 546
                                                           ||.|....|.  ||.
  Rat    73 -----------------------------------------------DDRERVHLPS--ATW--- 85

  Fly   547 DIPQRYIQIQMDCYPKENVAAASEGESSRADAPSITSGAAAGDELTQTEDLYTASEGVDGPDGDG 611
             :|:|...:|.|..|:::...|.|..:..|:...::.                          ||
  Rat    86 -VPERLSYLQKDASPQDSKVPAEEPSTQPANKGEVSR--------------------------DG 123

  Fly   612 SAGLHVTEDGV-VLRRPPRTGASAIKRRSGNRR--SRTKLKR-RCSINGHYYNRETSFFTPPYGS 672
            |..|...|:.| .|.|.....:..|:||..:|.  ...|::| |.|||||:||.:||.|||.|||
  Rat   124 SGPLQEEEEEVPQLMRTKSDASCIIQRRCKSRAPGEAQKIRRHRFSINGHFYNHKTSVFTPAYGS 188

  Fly   673 QMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRLKDDEYPLITRVTLGPHEDV 737
            ..:|.|:|.:||.:|:.|:|.|::|:..|..|:|:.|.::|||.:|||.|||||:|:..||.|.:
  Rat   189 VTNVRVNSTMTTQQVLTLLLNKFRVEDGPSEFALYTVHESGEQTKLKDCEYPLISRILHGPCEKI 253

  Fly   738 ARIFLVDSRKTDEISNEVAQFLNLSLPECRAILERYDQELAREVAKIKERYAELRRRIVSRMESL 802
            .:|||:::..::|:.::|||::...:|...:.:|:..:|..||:.|:..::..||..:..|:|.|
  Rat   254 VKIFLMEADLSEEVPHDVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMQQRLEQL 318

Fly 803 802
Rat 319 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	41/83 (49%)
		Nore1-SARAH	762..799	CDD:293125	8/36 (22%)
Rassf4	NP_001019446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..140		12/69 (17%)
Rassf4	NP_001019446.1	UBQ	176..262	CDD:294102	41/85 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351800
Domainoid	1	1.000	77	1.000	Domainoid score	I8636
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12926
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1043350at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46000
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22738
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.810