DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and Mical1

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_038954550.1	Gene:	Mical1 / 294520	RGDID:	1309386	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	69/368 - (18%)
Similarity:	112/368 - (30%)	Gaps:	131/368 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CHKCGKPVYFAERKQSIGYDWHPECLRCEECGKRLNPGQHAEHKSVP-----YC--HVPCYGALF 61
            |..|||.:|..||....|:.:|..|..|..|...|.||.:.::   |     ||  |:|
  Rat   681 CELCGKRLYILERFCVDGHFFHRGCFCCRTCEATLRPGGYGQY---PGDGYFYCLQHLP------ 736

  Fly    62 GPQLFGHGTRVESHKSYGVKGAQKPTGAQA---NGP-----------PLPRD--------HLES- 103
                  ...:.|:..:...:..:.||...:   :||           |:|..        .|.|
  Rat   737 ------QEDQKEADNNGSPENQELPTPGDSTTQSGPSSPVPPVTEASPVPSPSQPARRLIRLSSV 795

  Fly   104 ---KLKVYNQFYDN----------KSLEIRSREVNNRLVLEGALRVYWGVQGVIHLKEDDDQRIL 155
               :|...|...|:          ..|::....:.:..       :.|||.....:.|
  Rat   796 ERLRLSSLNIIPDSGVEPPPKPPRSCLDLAQESLKSSF-------MGWGVLRAPQVPE------- 846

  Fly   156 VRKRNSCRVSKAANESSSDKENEASESLAPPTTTTAEVDQLSTDVSLSESMTFDSCSLNEISELP 220
                   .:.|...|...::|.|..|...||        .|:.:|.....:|           .|
  Rat   847 -------AIEKGEEEEEEEEEEEEEEEELPP--------PLALEVEQGPDLT-----------AP 885

  Fly   221 TTPEDASANTTANSKEQTNGNVCNDDEDTTTTDSSGTLVEAPTASTSCVSSTLPSKLDRLEKLDW 285
            |.|:..                      .|...:||.:.:.||...:.:......::.|..|..
  Rat   886 TLPQSL----------------------LTLAKNSGDMTKYPTWRRTLMRRAKEEEMKRFCKAQ- 927

  Fly   286 DDIDDLLQVERRHNDKD---RIYETMPVKLPSSQSSSDSSPSK 325
                   .::||.|:.:   |..||..:||..:.....|||.|
  Rat   928 -------AIQRRLNEIEAAMRELETEGMKLEVALRKESSSPEK 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785	20/59 (34%)
		UBQ	660..744	CDD:294102
		Nore1-SARAH	762..799	CDD:293125
Mical1	XP_038954550.1	FAD_binding_3	85..>122	CDD:396193
		CH_MICAL1	506..611	CDD:409045
		LIM	681..734	CDD:413332	18/55 (33%)
		DUF3585	929..1056	CDD:403377	12/35 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900