DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and RASSF3

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_835463.1	Gene:	RASSF3 / 283349	HGNCID:	14271	Length:	238	Species:	Homo sapiens

Alignment Length:	239	Identity:	57/239 - (23%)
Similarity:	89/239 - (37%)	Gaps:	57/239 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 SEGVDGPDGDGSAGLHVTEDGVVLRRP---PRTGASAIKRRSG-----------------NRRSR 645
            |.|....:.|..............|.|   ||:|...:::...                 |....
Human     2 SSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVT 66

  Fly   646 TKLKRRCSINGHYYNRETSFF-------TPPY-------------GSQMSVWVSSMVTTTEVINL 690
            .|||...:.||.|    |.|.       .||.             |...::.:||..|..|||..
Human    67 DKLKMTLNSNGIY----TGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEA 127

  Fly   691 VLEKYKVDSSPGNFSLFIVRDNGEQK----RLKDDEYPLITRVTLGPHEDVARIFLVDSRKTDEI 751
            :|:|:.|..||..|:|: .|.:.|.:    :|.|.|:||..|:..||..|.....|.:
Human   128 LLKKFLVTESPAKFALY-KRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLRE------- 184

  Fly   752 SNEVAQFLNLSLPECRAILERYDQELAREVAKIKERYAELRRRI 795
             :|:.::...||||.:..|...|:|...::..:|.||...|:::
Human   185 -HEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKL 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	30/107 (28%)
		Nore1-SARAH	762..799	CDD:293125	11/34 (32%)
RASSF3	NP_835463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..48		5/21 (24%)
		UBQ	79..188	CDD:320785	32/121 (26%)
		Nore1-SARAH	192..231	CDD:318672	11/36 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740