DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and Rassf2

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001349795.1	Gene:	Rassf2 / 215653	MGIID:	2442060	Length:	326	Species:	Mus musculus

Alignment Length:	272	Identity:	87/272 - (31%)
Similarity:	147/272 - (54%)	Gaps:	34/272 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 QRYIQIQMDCYPKENVAAASEGESSRADAPSITSGAAAGDEL--------------TQTEDLYTA 600
            :|.|::||            :.:..|...|..:|...:|..|              .|..::...
Mouse    63 RRPIRLQM------------QDDHERIRPPPSSSSWHSGCNLGAQGTTLKPLTMPTVQISEVDMP 115

  Fly   601 SEGVDGPDGDGSAGLH-VTEDGVVLRRPPRTGASAIKRRSGNRRSRTKLKR----RCSINGHYYN 660
            .||::......|.||. |.||...|.   ||.:....||.||.|:.:..:|    |.|||||:||
Mouse   116 VEGLETHSPTDSRGLKPVQEDTPQLM---RTRSDVGVRRRGNVRTSSDQRRIRRHRFSINGHFYN 177

  Fly   661 RETSFFTPPYGSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRLKDDEYPL 725
            .:||.|||.|||..:|.::|.:||.:|:.|:|.|:|:::|...|:|::|..:||::|||..:|||
Mouse   178 HKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVVHTSGEKQRLKSSDYPL 242

  Fly   726 ITRVTLGPHEDVARIFLVDSRKTDEISNEVAQFLNLSLPECRAILERYDQELAREVAKIKERYAE 790
            |.|:..||.|.::::||::..:.:|::.:|||::...:|..::.:::..:|..|||.|:..:|..
Mouse   243 IARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQKLQEEEDREVEKLMRKYTV 307

  Fly   791 LRRRIVSRMESL 802
            ||..|..|:|.:
Mouse   308 LRLMIRQRLEEI 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	37/83 (45%)
		Nore1-SARAH	762..799	CDD:293125	10/36 (28%)
Rassf2	NP_001349795.1	RA_RASSF2	177..263	CDD:340741	37/85 (44%)
Rassf2	NP_001349795.1	Nore1-SARAH	277..316	CDD:374597	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848222
Domainoid	1	1.000	77	1.000	Domainoid score	I8817
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4168
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43912
orthoMCL	1	0.900	-	-		OOG6_105083
Panther	1	1.100	-	-	LDO	PTHR22738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5365
SonicParanoid	1	1.000	-	-		X2208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.780