DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and Rassf4

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_835146.3	Gene:	Rassf4 / 213391	MGIID:	2386853	Length:	322	Species:	Mus musculus

Alignment Length:	380	Identity:	103/380 - (27%)
Similarity:	172/380 - (45%)	Gaps:	95/380 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 LYGENSAMSKSFNCEHALRSID--------PTLINDTMNLRSSVGSPHSAQRQYALQKSGSATVT 493
            |..|..::.|::||.|..||..        ..:|...:|:...:..|...|.|
Mouse    20 LKSELLSLLKTYNCYHEGRSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQ------------ 72

  Fly   494 SRDQKKPYQQGRQLFEKGINRSKSGPSCFVYSDSDDDDEATLRPQRMATIRRSDIPQRYIQIQMD 558
                                               ||.|....|.  ||.    :|:|...:|.:
Mouse    73 -----------------------------------DDRERVHLPS--ATW----VPERLSYLQKE 96

  Fly   559 CYPKENVAAASE---GESSRADAPSITSGAAAGDELTQTEDLYTASEGVDGPDGDGSAGLHVTED 620
            ..|:::.....|   ..:::|:....:|||..|:|                            |:
Mouse    97 ASPQDSKVPTEEPGTQPANKAEVSGDSSGALEGEE----------------------------EE 133

  Fly   621 GVVLRRPPRTGASAIKRRSGNR--RSRTKLKR-RCSINGHYYNRETSFFTPPYGSQMSVWVSSMV 682
            ...|.|.....:..|:|||.:|  ....|::| |.|||||:||.:||.|||.|||..:|.|:|.:
Mouse   134 VPQLMRTKSDASCIIQRRSKSRAPSEAQKIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTM 198

  Fly   683 TTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRLKDDEYPLITRVTLGPHEDVARIFLVDSRK 747
            ||.:|:.|:|.|::|:..|..|:|:.|.::|||.:|||.|||||:|:..||.|.:.:|||:::..
Mouse   199 TTQQVLTLLLNKFRVEDGPSEFALYTVHESGEQTKLKDCEYPLISRILHGPCEKIVKIFLMEADL 263

  Fly   748 TDEISNEVAQFLNLSLPECRAILERYDQELAREVAKIKERYAELRRRIVSRMESL 802
            ::|:.::|||::...:|...:.:|:..:|..||:.|:..::..||..::.|:|.|
Mouse   264 SEEVPHDVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	41/83 (49%)
		Nore1-SARAH	762..799	CDD:293125	8/36 (22%)
Rassf4	NP_835146.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..161		16/92 (17%)
Rassf4	NP_835146.3	UBQ	176..262	CDD:294102	41/85 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848220
Domainoid	1	1.000	77	1.000	Domainoid score	I8817
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12926
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4168
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1043350at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43912
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5365
SonicParanoid	1	1.000	-	-		X2208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890