DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rassf and Mical3

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_036021853.1	Gene:	Mical3 / 194401	MGIID:	2442733	Length:	2252	Species:	Mus musculus

Alignment Length:	850	Identity:	169/850 - (19%)
Similarity:	260/850 - (30%)	Gaps:	287/850 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CHKCGKPVYFAERKQSIGYDWHPECLRCEECGKRLNPGQHA----EHKSVPYC--HVPCYGALFG 62
            |:.|.|.||..||..:.|..:|..|.:||.|...|....:|    :.|.  ||  |. ||
Mouse   916 CYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKF--YCKPHY-CY----- 972

  Fly    63 PQLFGHGTR----VESHKSYGVKGAQK--PTGAQANG------------PPLPRDHLESKLKVYN 109
             :|.|:..|    |.......||||.:  || |.|||            |....:.||
Mouse   973 -RLSGYAQRKRPAVAPLSGKEVKGALQDGPT-ADANGLASVAASSAERSPGTSMNGLE------- 1028

  Fly   110 QFYDNKSLEIRSREVNNRLVLEGALRVYWGVQGVIHLKE-------DDDQRILVRKRNSCRVSKA 167
                ..|:..|.|....|:.||...|   .|:.|..|:|       :.:...::.|.....|:.:
Mouse  1029 ----EPSIAKRLRGTPERIELENYRR---SVRQVEELEEVPEETQAEHNLSSVLDKGTEEDVASS 1086

  Fly   168 ANESSSDKENEASESLAPPTTTTAEVDQLST----------------------DVSLSESMTFDS 210
            ::||..::|.|..:          |.|.|.|                      :..|..|..|:.
Mouse  1087 SSESEMEEEEEEDD----------EDDHLPTSDLGGVPWKEAVRIHALLKGRSEEELEASKNFEP 1141

  Fly   211 CSLNEISELPTTPEDASANTTANSKEQTNGNVCNDDED---------TTTTDSSGTLVEAPTAST 266
            ....|..|.....|:........|.|:  |..|..|.:         .:..:..||.........
Mouse  1142 EEEEEEEEYEEEDEEYEEEEEEESSEE--GEYCPWDRELLQGQWLQHLSKEEEMGTCEAGNKRLQ 1204

  Fly   267 SCVSSTLPSKLDRLEKLDWDDIDDLLQVERRHNDKDRIYETMPVKLPSSQSSSDSSPSKTSTETT 331
            ..:::..|..:.  ..:.|..|       |....::|:       ||:|:||           |:
Mouse  1205 QIITAADPLAIQ--ADVHWTHI-------REREAEERM-------LPTSESS-----------TS 1242

  Fly   332 TTTESSSTQSASTNTSSTDDFMTATGSLTANTNTQNTTTVSTTETSLDNFETCDDATLKPIDFED 396
            ..|...|.:.|:....                                 .||...|   |:|.:|
Mouse  1243 RVTGLPSVRRAAVQAW---------------------------------LETVSGA---PLDEDD 1271

  Fly   397 FKRSVHQDYVNGANSFTEPNEGTLKRNQPIDPSRIHDSLKLYGENSAMSKSFNCEHALRSIDPTL 461
            .:.          ::.:||.|...:..:..||......|.....:..:......||.|:|  ...
Mouse  1272 LEE----------DADSEPAETEGEAAEDGDPGDTGAELDDQHWSDDIPSDAEAEHRLQS--QAK 1324

  Fly   462 INDTMNLRSSVG---SPHSAQRQYALQKSGSATVTSRDQKKPYQQGRQLF----EKGINRSKSGP 519
            :...:.||.|..   .|..|.:|   ::.|::.|:|..|....|.|  :|    ..|...:||..
Mouse  1325 VKAELELRVSENEEEKPSDAPKQ---EERGTSQVSSPSQPPEKQVG--VFSPARSPGTEEAKSPL 1384

  Fly   520 SCFVYSDSD------------------DDDEATLRPQRMATIRRSDI--PQRYIQIQMDCY---- 560
            :..|.|..:                  ::.:|.|.|.|...:...:.  |.....:|.:..
Mouse  1385 ATKVKSPEEPLFPTPLLLREKPKAEVPEEQKAVLSPIRSQPVALPEARSPTSPTSLQPESLLAPP 1449

  Fly   561 -----PKENVAAASEGE-SSRADAPSITSG--------AAAGDELTQTEDLYTASEGVDGPDGDG 611
                 |...:...|:.: ||.|..||.|..        |.....||   .|...|:|  .|....
Mouse  1450 TPPTPPPTQLPICSQPQPSSDASIPSPTKSPIRFQPVPAKTSTPLT---PLPVKSQG--DPKDRL 1509

  Fly   612 SAGLHVTEDGVVLRRPP--------------RTGASAIKRRSGNRRSRTKLKRRCSINGHYYNRE 662
            |..|.|.|   ||:|..              ..|.:.:.|..|:.
Mouse  1510 SGPLAVEE---VLKRSDLVEEFWMKSAEIRRSLGLTPVDRSKGSE-------------------- 1551

  Fly   663 TSFFTPPYGSQMSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRL-----KDDE 722
                 |...|..|..:|            |:.|.||.||.:..|.:::.....|||     ..|:
Mouse  1552 -----PSLPSPASKPIS------------LKSYSVDKSPQDEGLCLLKPPSVPKRLGLPKSAGDQ 1599

  Fly   723 YPLIT 727
            .||:|
Mouse  1600 PPLLT 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785	19/58 (33%)
		UBQ	660..744	CDD:294102	17/72 (24%)
		Nore1-SARAH	762..799	CDD:293125
Mical3	XP_036021853.1	FAD_binding_3	87..>274	CDD:396193
		CH_MICAL3	515..625	CDD:409100
		LIM_Mical	916..970	CDD:188823	18/55 (33%)
		PHA03307	1280..>1709	CDD:223039	75/376 (20%)
		DUF3585	2065..2233	CDD:403377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900