DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and ltd-1

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_495697.2	Gene:	ltd-1 / 174301	WormBaseID:	WBGene00003089	Length:	723	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	89/376 - (23%)
Similarity:	131/376 - (34%)	Gaps:	99/376 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CHKCGKPVYFAER----KQSIGYDWHPECLRCEECGKRL------NPGQHAEHKSVPYC--HVPC 56
            |::|||.||..::    |.|..:  |..|.:|..||.||      |.......|.| ||  |||.
Worm     7 CNRCGKQVYPTDKVGPLKDSTFF--HQGCFKCYICGTRLALKTYCNNRNDINDKEV-YCSNHVPI 68

  Fly    57 YGALFGPQLF--GHGTRVE--SHKSYG-----------VKGAQKPTGAQANGPPLPRD------- 99
            .|....|...  |.|..:|  :|...|           :..|.|.|......|.:..:
Worm    69 AGPHDLPMASTNGSGKNLENNNHVKNGNWIDAGLSDMKIAHAMKATQVARPYPKISHEGAKYVVD 133

  Fly   100 ----------HLESKLKVYNQFYDNKSLEIRSREVNNRLVLEGAL----RVYWGVQGVIHLKEDD 150
                      |.:.:..:|..|.|.:..|....|..|....|.||    :.|  .:|..::|:||
Worm   134 YDTQTRLELLHRKDEDDLYESFQDKRVREAEEFEKENTEEWEKALAEFAKKY--EKGQSNMKKDD 196

  Fly   151 DQRILVRKRNSCRVSKAANESSSDKENEASESLAPPTTTTAEVDQLSTDVSLSESMTFDSCSLNE 215
                |:|:....|..|.....:..||.|..:        |||:    .|....|.:.....|.:|
Worm   197 ----LIRQLTIKREKKLETLHTKRKERERHQ--------TAEL----VDRQAKEMLELFKASRSE 245

  Fly   216 ISEL--PTTPEDASANTTANSKEQTNGNVCNDDEDTTTTDSSGTLVEAPTASTSCVSSTLPSKLD 278
            .|.|  |:||......:            |:..|..||||...::.|   .:..|..:.:.|..|
Worm   246 YSNLQYPSTPPPPVPPS------------CSKREIYTTTDYFSSIDE---VAIHCARNEVASFTD 295

  Fly   279 RLEKLD---WDDIDDLLQVERRHNDKDRIYETMPVKLPSSQSSSDSSPSKT 326
            .:..|.   ..|:|    |.|      .||..:.:|..::....||..:.|
Worm   296 LIRTLSSGARSDVD----VAR------AIYRWITIKNLNTMIFDDSIQNDT 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785	23/64 (36%)
		UBQ	660..744	CDD:294102
		Nore1-SARAH	762..799	CDD:293125
ltd-1	NP_495697.2	LIM_Ltd-1	7..66	CDD:188827	20/61 (33%)
ltd-1	NP_495697.2	CYK3	<295..>484	CDD:227604	12/52 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810