DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rassf and RASSF1

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_733832.1	Gene:	RASSF1 / 11186	HGNCID:	9882	Length:	344	Species:	Homo sapiens

Alignment Length:	177	Identity:	51/177 - (28%)
Similarity:	81/177 - (45%)	Gaps:	32/177 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   625 RRPPRTGASAIKRRSGNRRSRTKLKRRCSINGHYYNRETSFFTPPYGSQMSVWVSSMVTTTEVIN 689
            ::||    |....|.|..|. |.::||           |||:.|. .:...:.|.|.....|||.
Human   184 KKPP----SLQDARRGPGRG-TSVRRR-----------TSFYLPK-DAVKHLHVLSRTRAREVIE 231

  Fly   690 LVLEKYKVDSSPGNFSLFIVRDNGEQ---KRLKDDEYPLITRVTLGPHEDVARIFLVDSRKTDEI 751
            .:|.|:.|...|..|:||...:...|   ::|.|||.||..|:..|| .|.|..|::....:.|:
Human   232 ALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGP-SDKALSFVLKENDSGEV 295

  Fly   752 SNEVAQFLNLSLPECR---AILERYDQELAREVAKIKERYAELRRRI 795
            :.:.     .|:||..   .||:|.::|..|:   |.::|:..|::|
Human   296 NWDA-----FSMPELHNFLRILQREEEEHLRQ---ILQKYSYCRQKI 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	29/86 (34%)
		Nore1-SARAH	762..799	CDD:293125	12/37 (32%)
RASSF1	NP_733832.1	Mediates interaction with E4F1. /evidence=ECO:0000269\|PubMed:14729613	2..119
		C1_1	52..105	CDD:278556
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..203		7/23 (30%)
		RASSF1_RA	198..293	CDD:176373	33/108 (31%)
		Nore1-SARAH	299..338	CDD:293125	12/44 (27%)
		MOAP1-binding	315..318		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157838
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S6693
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.690