DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rassf and rassf2b

DIOPT Version :9

Sequence 1:	NP_651126.3	Gene:	Rassf / 42734	FlyBaseID:	FBgn0039055	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001002195.1	Gene:	rassf2b / 100006341	ZFINID:	ZDB-GENE-041221-6	Length:	316	Species:	Danio rerio

Alignment Length:	390	Identity:	105/390 - (26%)
Similarity:	184/390 - (47%)	Gaps:	89/390 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 QPIDPSRIHDSLKLYGENSAMSKSFNCEHALRSIDPTLINDTMNLRSSVGSPHSAQRQYALQKSG 488
            :.:|..:|.     .|||..:|||....| |::.:.....|.:.||         .|:
Zfish     2 ESVDSDKIQ-----VGENKFVSKSVILSH-LKTYNVYFEGDALQLR---------HRE------- 44

  Fly   489 SATVTSRDQKKPYQQGRQLFEK------GINRSKSGPSCFVYSDSDDDDEATLRPQRMATIRRSD 547
                         ::|..:.|.      |::|    |......|..|    |.||:.:.|
Zfish    45 -------------EEGELVIEGLLNVFWGVHR----PIRLQMQDEKD----TGRPRPLVT----- 83

  Fly   548 IPQRYIQIQMDCYPKENVAAASEGESSRADAPSITSGAAAGDELTQ--TEDLYTASEGVDGPDGD 610
                         |.:    .:..:|:....|.::....|.:|.::  :|:...|.||
Zfish    84 -------------PLD----INTVKSNETHQPPVSIEVTAAEERSRDSSEEKQEAGEG------- 124

  Fly   611 GSAGLHVTEDGVVLRRPPRTGASAIKRRSGNRR--SRTKLKRRCSINGHYYNRETSFFTPPYGSQ 673
                 |  .:..:..|..||.:....|:.|.||  .|...:.|||.|||:||.:|:.|||..||.
Zfish   125 -----H--HESTLSDRLNRTRSDVSGRKIGGRRLGIRRVQRHRCSFNGHFYNHKTAVFTPAVGSV 182

  Fly   674 MSVWVSSMVTTTEVINLVLEKYKVDSSPGNFSLFIVRDNGEQKRLKDDEYPLITRVTLGPHEDVA 738
            .:|.|:|.:||::|:.::|.|:|:::||..|||::|..:||:.:||.:::||:.||..||.|.|:
Zfish   183 TNVRVNSCMTTSQVMRVLLNKFKIENSPDEFSLYLVHTSGERHQLKPNDHPLLVRVLQGPCEQVS 247

  Fly   739 RIFLVDSRKTDEISNEVAQFLNLSLPECRAILERYDQELAREVAKIKERYAELRRRIVSRMESLK 803
            ::||::..:.:|::.:|||::...||..::.:.:..:|..||:.|:|.||||::|.|...|::.|
Zfish   248 KMFLMEMDQVEEVTYDVAQYIKFELPVLQSFIAKLQEEEEREMQKLKTRYAEMQRIIKRCMQTSK 312

Fly 804 803
Zfish 313 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rassf	NP_651126.3	LIM_TLP_like	4..57	CDD:188785
		UBQ	660..744	CDD:294102	36/83 (43%)
		Nore1-SARAH	762..799	CDD:293125	13/36 (36%)
rassf2b	NP_001002195.1	UBQ	169..255	CDD:294102	36/85 (42%)
rassf2b	NP_001002195.1	Nore1-SARAH	269..308	CDD:293125	13/38 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593633
Domainoid	1	1.000	76	1.000	Domainoid score	I8863
eggNOG	1	0.900	-	-		E1_KOG4239
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3809
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1043350at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25718
orthoMCL	1	0.900	-	-		OOG6_105083
Panther	1	1.100	-	-	O	PTHR22738
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760