DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cow and CD74

DIOPT Version :9

Sequence 1:	NP_001262857.1	Gene:	Cow / 42733	FlyBaseID:	FBgn0039054	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_016865578.1	Gene:	CD74 / 972	HGNCID:	1697	Length:	321	Species:	Homo sapiens

Alignment Length:	244	Identity:	58/244 - (23%)
Similarity:	85/244 - (34%)	Gaps:	78/244 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 MRN---YNEVVEKQQQKFNKNSN-LNAYPSKSAECKPQQLTAIGNRL--LDWFSVIMADSKKRRQ 456
            |:|   |..:.|.......:|:: |..||...... |:.|..:.|.:  :||
Human   128 MQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSF-PENLRHLKNTMETIDW------------- 178

  Fly   457 HSQKSKAHFPPACKTEAKWMFGHLDLNNDGQLSLQEMYDLEHDQNERCIKPFIDTCDLDTDSSIN 521
                         |....||...|            ::::.....|:  ||      .|....:.
Human   179 -------------KVFESWMHHWL------------LFEMSRHSLEQ--KP------TDAPPKVL 210

  Fly   522 TREWCRCFEKTDRPCAAVRRRIAGDFAGEIGAYAPDCDIQGFYKPTQCHNSVGVCWCVDKHGVEF 586
            |    :|.|:.....|.           ..|::.|.||..|.|.|.||:.|:|.||||..:|.|.
Human   211 T----KCQEEVSHIPAV-----------HPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEV 260

  Fly   587 ANTRTRGKPNCESVVNNAASLTSDDEDEG----ADDEDSAEGSADQMLV 631
            .|||:||..||      :.||..:|...|    ..|....:|.|:..||
Human   261 PNTRSRGHHNC------SESLELEDPSSGLGVTKQDLGPGKGLAEGHLV 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624
		SPARC_EC	427..539	CDD:238155	17/113 (15%)
		SPARC_Ca_bdg	427..526	CDD:287550	14/100 (14%)
		TY	535..597	CDD:238114	23/61 (38%)
CD74	XP_016865578.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960