Protein Alignment Cow and SPOCK1

DIOPT Version :9

• Sequence 1: NP_001262857.1
• Gene: Cow / 42733
• FlyBaseID: FBgn0039054
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_004589.1
• Gene: SPOCK1 / 6695
• HGNCID: 11251
• Length: 439
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 133/619 - (21%)
• Similarity: 191/619 - (30%)
• Gaps: 291/619 - (47%)

  Fly    45 DEINKNTQSNKNLGEHKRWIHDPSSDLCRPLNCKKREICLLEDEFSAVCVSKKELHKNRDEIITK 109
            |:..:|...||...:    ..|||.|.|..:.|...::|:.:|..:|:|||:|.|
Human    63 DDYFRNWNPNKPFDQ----ALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHL---------- 113

  Fly   110 AKYLEEEAKRRVNQQDNQDSQDAEDINNDDEDNSSDGGSSNSSPTGTNNAQASVQGNEETDDEDK 174
               |..:.|..|.|:.
Human   114 ---LPRQKKGNVAQKH------------------------------------------------- 126

  Fly   175 SLSLGDDDESKEDDVFYENSIAAGDKQQQQQQLSQPAAGPSVIQQDDDEELDNCKPCPVAKPTFL 239
                                                ..|||        .|..|||||||:...:
Human   127 ------------------------------------WVGPS--------NLVKCKPCPVAQSAMV 147

  Fly   240 CGADNRTYSSLCRLDYHNCIHSTSIRIACKGFCPCKEIVDGKRLQRISGYNNKYNKKISLDQQQQ 304
            ||:|..:|:|.|:|::|.|....|:...|.|.|||
Human   148 CGSDGHSYTSKCKLEFHACSTGKSLATLCDGPCPC------------------------------ 182

  Fly   305 QQQQQQQQQQQQQAYKDSNNNNIMMNSGNIMGGNNNDFNTIMNDKEDNNRHNNHINAQYTFTPEE 369
                                                                         .||.
Human   183 -------------------------------------------------------------LPEP 186

  Fly   370 IKYDNKHYKYLKYTAYKKDSKYQEDKHKMRNYNEVVEKQQQKFNKNSNLNAYPSKSAECKPQQLT 434
                                  :..|||                         ::.:.|..::|.
Human   187 ----------------------EPPKHK-------------------------AERSACTDKELR 204

  Fly   435 AIGNRLLDWFSVIMADSKK--RRQHSQKSKAHFP----PACKTEAKWMFGHLDLNNDGQLSLQEM 493
            .:.:||.|||..:..|:.:  :...|..::..|.    |.||....|||..||:|.|..|...|:
Human   205 NLASRLKDWFGALHEDANRVIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEI 269

  Fly   494 YDLEHDQNERCIKPFIDTCDLDTDSSINTREWCRCFEKT-DRPCAAVRRRIAGDFAGE--IGAYA 555
            ..:..|:.|.||||..::||...|..::..|||.||:|. ..||.....||.....|:  :||:.
Human   270 NAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFI 334

  Fly   556 PDCDIQGFYKPTQCHNSVGVCWCVDKHGVEFANTRTRGKPNCE-------------SVV------ 601
            |.|:.:|:||.||||.|.|.||||||:|.|.|.:|.:|..:||             |||
Human   335 PRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLE 399

  Fly   602 ---------------NNAASLTSDDEDEGADDED 620
                           .:..::|.|||||..|.||
Human   400 YERELGPKDKEGKLRVHTRAVTEDDEDEDDDKED 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624	12/31 (39%)
		SPARC_EC	427..539	CDD:238155	39/118 (33%)
		SPARC_Ca_bdg	427..526	CDD:287550	32/104 (31%)
		TY	535..597	CDD:238114	29/63 (46%)
SPOCK1	NP_004589.1	Kazal_2	139..178	CDD:284958	15/38 (39%)
		SPARC_Ca_bdg	196..302	CDD:287550	32/105 (30%)
		SPARC_EC	197..315	CDD:238155	39/117 (33%)
		TY	312..372	CDD:238114	28/59 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..439		9/19 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149374
Domainoid	1	1.000	74	1.000	Domainoid score	I9139
eggNOG	1	0.900	-	-		E1_KOG3555
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3289
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1235834at2759
OrthoFinder	1	1.000	-	-		FOG0002140
OrthoInspector	1	1.000	-	-		otm41577
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1424
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760