Protein Alignment Cow and SPOCK3

DIOPT Version :9

• Sequence 1: NP_001262857.1
• Gene: Cow / 42733
• FlyBaseID: FBgn0039054
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_016863746.1
• Gene: SPOCK3 / 50859
• HGNCID: 13565
• Length: 445
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 140/690 - (20%)
• Similarity: 211/690 - (30%)
• Gaps: 330/690 - (47%)

  Fly     3 HSPLI---------ASACLALVLMSSSLIGSTEARNKKKYVGETGGDFE---FIDE---INKNTQ 52
            |.||.         |..|:......|..:.:..|      |...||..:   |:|:   :...:|
Human     4 HPPLCLLSQMLKVSAVLCVCAAAWCSQSLAAAAA------VAAAGGRSDGGNFLDDKQWLTTISQ 62

  Fly    53 SNKNLGE---------HKRW--------IHDPSSDLCRPLNCKKREICLLEDEFSAVCVSKKEL- 99
            .:|.:|:         .:.|        ..||:.|.|..:.|.:.::|:.:|..:|||:|.:.|
Human    63 YDKEVGQWNKFRDDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLT 127

  Fly   100 HKNRDEIITKAKYLEEEAKRRVNQQDNQDSQDAEDINNDDEDNSSDGGSSNSSPTGTNNAQASVQ 164
            |:.::
Human   128 HRMKE------------------------------------------------------------ 132

  Fly   165 GNEETDDEDKSLSLGDDDESKEDDVFYENSIAAGDKQQQQQQLSQPAAGPSVIQQDDDEELDNCK 229
                                            ||...:|.:       ||.         |..||
Human   133 --------------------------------AGVDHRQWR-------GPI---------LSTCK 149

  Fly   230 PCPVAKPTFLCGADNRTYSSLCRLDYHNCIHSTSIRIACKGFCPCKEIVDGKRLQRISGYNNKYN 294
            .|||..|:.:||:|..|||..|:|:|..|:....|.:.|:|.|||.
Human   150 QCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCP------------------- 195

  Fly   295 KKISLDQQQQQQQQQQQQQQQQQAYKDSNNNNIMMNSGNIMGGNNNDFNTIMNDKEDNNRHNNHI 359
                                                                :||.
Human   196 ----------------------------------------------------SDKP--------- 199

  Fly   360 NAQYTFTPEEIKYDNKHYKYLKYTAYKKDSKYQEDKHKMRNYNEVVEKQQQKFNKNSNLNAYPSK 424
                |.|...:|
Human   200 ----TSTSRNVK----------------------------------------------------- 207

  Fly   425 SAECKPQQLTAIGNRLLDWFSVIM---ADSKKRRQHSQKSKAHFP----PACKTEAKWMFGHLDL 482
             ..|...:...:.|||.|||..:.   :.:||.:...:..::.|.    |.||....|||..||.
Human   208 -RACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWMFNRLDT 271

  Fly   483 NNDGQLSLQEMYDLEHDQNERCIKPFIDTCDLDTDSSINTREWCRCFEK-TDRPC----AAVRRR 542
            |.|..|...|:..:..|:||:|.|.|.::||...||.|:..|||.||:: .|.||    :.:::|
Human   272 NYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKR 336

  Fly   543 IAGDFAGE---IGAYAPDCDIQGFYKPTQCHNSVGVCWCVDKHGVEFANTRTRGKPNC------- 597
                 .|.   :|.|.|.||..|:|||||||.|||.|||||::|.|...:|..|..:|
Human   337 -----QGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEIS 396

  Fly   598 ------------------ESVVNNAASLTSDDEDEGADDE 619
                              :.::|:...:..||||||.||:
Human   397 GDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDD 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624	13/31 (42%)
		SPARC_EC	427..539	CDD:238155	41/123 (33%)
		SPARC_Ca_bdg	427..526	CDD:287550	34/105 (32%)
		TY	535..597	CDD:238114	29/68 (43%)
SPOCK3	XP_016863746.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149372
Domainoid	1	1.000	74	1.000	Domainoid score	I9139
eggNOG	1	0.900	-	-		E1_KOG3555
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3289
Isobase	1	0.950	-	0	Normalized mean entropy	S6033
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1235834at2759
OrthoFinder	1	1.000	-	-		FOG0002140
OrthoInspector	1	1.000	-	-		otm41577
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5366
SonicParanoid	1	1.000	-	-		X1424
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740