Protein Alignment Cow and Cd74

DIOPT Version :10

• Sequence 1: NP_001262857.1
• Gene: Cow / 42733
• FlyBaseID: FBgn0039054
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_006254823.1
• Gene: Cd74 / 25599
• RGDID: 2313
• Length: 280
• Species: Rattus norvegicus
• Alignment Length: 274
• Identity: 59/274 - (21%)
• Similarity: 97/274 - (35%)
• Gaps: 90/274 - (32%)

  Fly   382 YTAYKKDSKYQEDKHKMRNYNEVVEKQQQKFNKNSNLNAYPSKSAECKPQQL-TAIGNRLLDWFS 445
            |..|::..:.  ||..:.:.|..:|..:.|.         |..:....|.:: |.:..|.|...:
  Rat    53 YFLYQQQGRL--DKLTVTSQNLQLENLRMKL---------PKSAKPVSPMRMATPLLMRPLSMDN 106

  Fly   446 VIMADSKKRRQHSQKSKAHFPPACKTEAKWMFGHLDLNNDGQLSLQEM-----YDLEHDQNERCI 505
            ::.|..|...::...::.|..            || |...|.::..::     .:|:|.:|
  Rat   107 MLQAPVKNVTKYGNMTQDHVM------------HL-LTKSGPVNYPQLKGSFPENLKHLKN---- 154

  Fly   506 KPFIDTCDLDTDSSINTREWCRCFEK--------------------TDRPCAAVRRRIAGDFAGE 550
                         |:|..:| :.||.                    |..|...:.:  ..:....
  Rat   155 -------------SMNGLDW-KVFESWMKQWLLFEMSKNSLEEKQPTQTPPKVLTK--CQEEVSH 203

  Fly   551 I-----GAYAPDCDIQGFYKPTQCHNSVGVCWCVDKHGVEFANTRTRGKPNCESVVNNAASLTSD 610
            |     ||:.|.||..|.|.|.|||.|.|.||||..:|.|..:|::||:.||
  Rat   204 IPDVHPGAFRPKCDENGNYMPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNC------------- 255

  Fly   611 DEDEGADDEDSAEG 624
              .|..|.||.:.|
  Rat   256 --SEPLDMEDPSSG 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624
		EFh_SPARC_TICN	428..533	CDD:320011	19/130 (15%)
		EF-hand motif	469..500	CDD:320011	6/35 (17%)
		EF-hand motif	501..533	CDD:320011	6/51 (12%)
		TY	535..597	CDD:238114	24/66 (36%)
Cd74	XP_006254823.1	MHC2-interact	1..113	CDD:462750	13/70 (19%)
		MHCassoc_trimer	120..185	CDD:462614	13/95 (14%)
		TY	196..255	CDD:238114	23/60 (38%)