DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cow and Cd74

DIOPT Version :9

Sequence 1:	NP_001262857.1	Gene:	Cow / 42733	FlyBaseID:	FBgn0039054	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_006254823.1	Gene:	Cd74 / 25599	RGDID:	2313	Length:	280	Species:	Rattus norvegicus

Alignment Length:	277	Identity:	62/277 - (22%)
Similarity:	98/277 - (35%)	Gaps:	95/277 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 TAYKKDSKYQE----DKHKMRNYNEVVEKQQQKFNKNSNLNAYPSKSAECKPQQL-TAIGNRLLD 442
            |||   ..||:    ||..:.:.|..:|..:.|.         |..:....|.:: |.:..|.|.
  Rat    51 TAY---FLYQQQGRLDKLTVTSQNLQLENLRMKL---------PKSAKPVSPMRMATPLLMRPLS 103

  Fly   443 WFSVIMADSKKRRQHSQKSKAHFPPACKTEAKWMFGHLDLNNDGQLSLQEM-----YDLEHDQNE 502
            ..:::.|..|...::...::.|..            || |...|.::..::     .:|:|.:|
  Rat   104 MDNMLQAPVKNVTKYGNMTQDHVM------------HL-LTKSGPVNYPQLKGSFPENLKHLKN- 154

  Fly   503 RCIKPFIDTCDLDTDSSINTREWCRCFEK--------------------TDRPCAAVRRRIAGDF 547
                            |:|..:| :.||.                    |..|...:.:  ..:.
  Rat   155 ----------------SMNGLDW-KVFESWMKQWLLFEMSKNSLEEKQPTQTPPKVLTK--CQEE 200

  Fly   548 AGEI-----GAYAPDCDIQGFYKPTQCHNSVGVCWCVDKHGVEFANTRTRGKPNCESVVNNAASL 607
            ...|     ||:.|.||..|.|.|.|||.|.|.||||..:|.|..:|::||:.||
  Rat   201 VSHIPDVHPGAFRPKCDENGNYMPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNC---------- 255

  Fly   608 TSDDEDEGADDEDSAEG 624
                 .|..|.||.:.|
  Rat   256 -----SEPLDMEDPSSG 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624
		SPARC_EC	427..539	CDD:238155	21/137 (15%)
		SPARC_Ca_bdg	427..526	CDD:287550	16/104 (15%)
		TY	535..597	CDD:238114	24/66 (36%)
Cd74	XP_006254823.1	MHC2-interact	1..113	CDD:401300	16/73 (22%)
		MHCassoc_trimer	120..185	CDD:400954	13/95 (14%)
		TY	196..255	CDD:238114	23/60 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960