DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cow and Cd74

DIOPT Version :9

Sequence 1:	NP_001262857.1	Gene:	Cow / 42733	FlyBaseID:	FBgn0039054	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001036070.1	Gene:	Cd74 / 16149	MGIID:	96534	Length:	279	Species:	Mus musculus

Alignment Length:	262	Identity:	59/262 - (22%)
Similarity:	100/262 - (38%)	Gaps:	66/262 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 YTAYKKDSKYQEDKHKMRNYNEVVEKQQQKFNKNSNLNAYPSKSAECKP----QQLTAIGNRLLD 442
            |..|::..:.  ||..:.:.|..:|..:.|..|::            ||    :..|.:..|.:.
Mouse    52 YFLYQQQGRL--DKLTITSQNLQLESLRMKLPKSA------------KPVSQMRMATPLLMRPMS 102

  Fly   443 WFSVIMADSKKRRQHSQKSKAHFPPACKTEAKWMFGHLDLNNDGQLSLQEM-----YDLEHDQN- 501
            ..::::...|...::...::.|..            || |...|.|...::     .:|:|.:|
Mouse   103 MDNMLLGPVKNVTKYGNMTQDHVM------------HL-LTRSGPLEYPQLKGTFPENLKHLKNS 154

  Fly   502 ---------ERCIKPFIDTCDLDTDSSINTREWCRCFEKTDRPCAAVRRRIAGDFAGEIGAYAPD 557
                     |..:|.:     |..:.|.|:.|..:..|...:.....:..::...|...||:.|.
Mouse   155 MDGVNWKIFESWMKQW-----LLFEMSKNSLEEKKPTEAPPKVLTKCQEEVSHIPAVYPGAFRPK 214

  Fly   558 CDIQGFYKPTQCHNSVGVCWCVDKHGVEFANTRTRGKPNCESVVNNAASLTSDDEDEGADDEDSA 622
            ||..|.|.|.|||.|.|.||||..:|.|..:|::||:.||               .|..|.||.:
Mouse   215 CDENGNYLPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNC---------------SEPLDMEDLS 264

  Fly   623 EG 624
            .|
Mouse   265 SG 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cow	NP_001262857.1	KAZAL	<240..272	CDD:197624
		SPARC_EC	427..539	CDD:238155	21/130 (16%)
		SPARC_Ca_bdg	427..526	CDD:287550	20/117 (17%)
		TY	535..597	CDD:238114	23/61 (38%)
Cd74	NP_001036070.1	MHC2-interact	1..111	CDD:286400	12/72 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		MHCassoc_trimer	119..184	CDD:285980	15/82 (18%)
		TY	195..254	CDD:238114	23/58 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960