DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6733 and ACY1

DIOPT Version :10

Sequence 1:NP_651123.1 Gene:CG6733 / 42731 FlyBaseID:FBgn0039052 Length:401 Species:Drosophila melanogaster
Sequence 2:NP_000657.1 Gene:ACY1 / 95 HGNCID:177 Length:408 Species:Homo sapiens


Alignment Length:400 Identity:179/400 - (44%)
Similarity:251/400 - (62%) Gaps:11/400 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 ENNEEIKIFREYLRIPTVHPDVDYTACVEFLKRQASSLNLPVEVVYPAVQTKP---VVIIKWEGS 68
            |.:..:.:||:||||.||.|..||.|.|.|.:..|..|.|..:    .|:..|   |.::.|.|:
Human     8 EEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQ----KVEVAPGYVVTVLTWPGT 68

  Fly    69 QPELSSIVLNSHTDVVPVFREKWTHEPFSADIDEEGRIFARGTQDMKSVGTQYLGAIRLLKASGF 133
            .|.||||:|||||||||||:|.|:|:||.|..|.||.|:|||.||||.|..|||.|:|.||..|.
Human    69 NPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRLKVEGH 133

  Fly   134 KPKRNLYVTFVPDEETGGHLGMAEFVKTDYYKKMNAGFSLDEGATSESDVHHLFYAERLRWGLKL 198
            :..|.:::|||||||.|||.||..||:...:..:.|||:||||..:.:|...:||:||..|.:::
Human   134 RFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRV 198

  Fly   199 KVSGTSGHGSLLLPNTAGVKLNYLVNKLTEFRTSQVENLARDSSLSKGDVTTVNLTQLSGGVQSN 263
            ..:|..||.|..:.:||..||:.:||.:..||..:.:.|..:..|.:|.||:||||:|.|||..|
Human   199 TSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYN 263

  Fly   264 VVPPLFEAVFDIRIAITVNVVAFEKQIRDWCEEAGGGIEIDFFQK--EPYIGPTKLDNSNPYWLA 326
            |:|....|.||.|:|..|:..|||:|::.||:.||.|:.::|.||  .|.:.||  |:|||:|.|
Human   264 VIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPT--DDSNPWWAA 326

  Fly   327 VKAAIDELGLKVHPIVCPGATDSRFIREKGTPAIGFSPIINTTMRIHDHDEFLQADVYLNGIDVY 391
            ......::.|.:.|.:.|.|||:|:||..|.||:||||:..|.:.:|||||.|...|:|.|:|:|
Human   327 FSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIY 391

  Fly   392 KKIIRNLAEV 401
            .:::..||.|
Human   392 TRLLPALASV 401

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6733NP_651123.1 M20_AcylaseI_like 8..399 CDD:349898 175/395 (44%)
ACY1NP_000657.1 M20_AcylaseI_like 9..399 CDD:349898 175/395 (44%)

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