DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6733 and CPS1

DIOPT Version :9

Sequence 1:	NP_651123.1	Gene:	CG6733 / 42731	FlyBaseID:	FBgn0039052	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_012363.1	Gene:	CPS1 / 853267	SGDID:	S000003708	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	497	Identity:	110/497 - (22%)
Similarity:	186/497 - (37%)	Gaps:	124/497 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NEEIKIFREYLRIPTVHPDVDYTAC--VEFLKRQASSLNLPVEVVYPAVQ--------TKPVVII 63
            |..|:.....:|||||..|.:....  .:|.| ....|:...|..:|.:.        .:..::.
Yeast    88 NSSIEKLSNAVRIPTVVQDKNPNPADDPDFYK-HFYELHDYFEKTFPNIHKHLKLEKVNELGLLY 151

  Fly    64 KWEGSQPELSSIVLNSHTDVVPVFRE---KWTHEPFSADID-EEGRIFARGTQDMKSVGTQYLGA 124
            .||||.|:|..::|.:|.|||||..|   .|...|||...| |...::.||:.|.|::......|
Yeast   152 TWEGSDPDLKPLLLMAHQDVVPVNNETLSSWKFPPFSGHYDPETDFVWGRGSNDCKNLLIAEFEA 216

  Fly   125 IRLLKASGFKPKRNLYVTFVPDEETGGHLG---MAEFVKTDY-----YKKMNAG---FSLDEGAT 178
            |..|...||||.|.:.::...|||..|.||   :|.|:...|     |..::.|   ..:|:...
Yeast   217 IEQLLIDGFKPNRTIVMSLGFDEEASGTLGAASLASFLHERYGDDGIYSIIDEGEGIMEVDKDVF 281

  Fly   179 SESDVHHLFYAERLRWGLKLKVSGTSGHGSLLLPNTAGVKLNYLVNKLTEFRTSQ---------- 233
            ..:.::    ||:.....::.:.|..||.|:...:|.   :......:|||..:.
Yeast   282 VATPIN----AEKGYVDFEVSILGHGGHSSVPPDHTT---IGIASELITEFEANPFDYEFEFDNP 339

  Fly   234 ------------------------------------VENLARDSSLSKGDVTTVNLTQLSGGVQS 262
                                                ||.::..|.|.....||..:..::|||::
Yeast   340 IYGLLTCAAEHSKSLSKDVKKTILGAPFCPRRKDKLVEYISNQSHLRSLIRTTQAVDIINGGVKA 404

  Fly   263 NVVPPLFEAVFDIRIAITVNVV-AFEKQI---RDWCEEAGGGIE---IDFFQKEPYIG------- 313
            |.:|.....:.:.||.:..:|. .||:.|   :...|:.|.|:.   .|:...|..:|
Yeast   405 NALPETTRFLINHRINLHSSVAEVFERNIEYAKKIAEKYGYGLSKNGDDYIIPETELGHIDITLL 469

  Fly   314 ----PTKLD-NSNPYWLAVKAAIDEL----------------GLKVHPIVCPGATDSRF---IRE 354
                |..|. :|.|.|..:...|.::                ||      ..|.||:::   :.:
Yeast   470 RELEPAPLSPSSGPVWDILAGTIQDVFENGVLQNNEEFYVTTGL------FSGNTDTKYYWNLSK 528

  Fly   355 KGTPAIGFSPIINTTMRIHDHDEFLQADVYLNGID-VYKKII 395
            .....:|....|:....:|..:|.:....:|:.|. ||:.|:
Yeast   529 NIYRFVGSIIDIDLLKTLHSVNEHVDVPGHLSAIAFVYEYIV 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6733	NP_651123.1	Ac-peptdase-euk	1..401	CDD:273850	110/497 (22%)
CG6733	NP_651123.1	M20_AcylaseI_like	8..399	CDD:193524	110/497 (22%)
CPS1	NP_012363.1	M20_yscS	91..570	CDD:349923	108/492 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I2755
eggNOG	1	0.900	-	-		E1_COG0624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46677
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2059
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840