DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6733 and DUG2

DIOPT Version :9

Sequence 1:	NP_651123.1	Gene:	CG6733 / 42731	FlyBaseID:	FBgn0039052	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_009840.3	Gene:	DUG2 / 852584	SGDID:	S000000485	Length:	878	Species:	Saccharomyces cerevisiae

Alignment Length:	479	Identity:	101/479 - (21%)
Similarity:	168/479 - (35%)	Gaps:	121/479 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NNEE-IKIFREYLRIPTVHPDVDYT------ACVEFLKRQASSLNLPVEVVYPAVQ-TKPVVIIK 64
            |||| :...||.:...||....|.|      .|..:|::...........::|... ..|||...
Yeast   433 NNEEMLNTLRELISFQTVSQSKDTTNTLSLRRCAIYLQQLFLKFGATNSQLFPLPDGGNPVVFAY 497

  Fly    65 WEG----SQ---PELSSIVLNSHTDVVP---VFREKWTHEPFSADIDEEGRIFARGTQDMKSVGT 119
            ::|    ||   .:...|:...|.||:.   .|  .|..:||:... |.|.:..||..|.|....
Yeast   498 FQGNGKVSQVKGAKKKRILWYGHYDVISSGNTF--NWNTDPFTLTC-ENGYLKGRGVSDNKGPLV 559

  Fly   120 QYLGAIRLLKASGFKPKRNLYVTFVPDEETGGHLGMAEFVKTDYYKKMNAGFSLDEGATSES--- 181
            ..:.::..|...|  ...|..|..|...|..|...:.: |...|:..:  |..:|....|.|
Yeast   560 SAIHSVAYLFQQG--ELVNDVVFLVEGSEEIGSASLKQ-VCEKYHDII--GKDIDWILLSNSTWV 619

  Fly   182 DVHHLFYAERLRWGLK------LKV--------SGTSG--------------------HGSLLLP 212
            |..|    ..|.:||:      :||        ||.:|                    ...:::|
Yeast   620 DQEH----PCLNYGLRGVINAQIKVWSDKPDGHSGLNGGVYDEPMVNLVKIVSKLQNEQNEIMIP 680

  Fly   213 NTAGVKLNYLV-------NKLTEF----RTSQVENLARDSSLSKGDVTTVNLTQLSGGVQSNVVP 266
            |... .|..|.       .|:||.    ..:.|::|..:.:.....:|||   :.||.....|:|
Yeast   681 NFYS-PLKDLTEEEYQRFQKITELANIDENTTVQDLITNWTKPSLSMTTV---KFSGPGNITVIP 741

  Fly   267 PLFEAVFDIRIAITVNVVAFEKQIRDWCEE------AGGGIEIDFF-QKEPYIGPTKLDNSNPYW 324
            ........||:....:|...::.::.:.||      :...:||... :.|.::|    |.:|..:
Yeast   742 KSVTMGISIRLVPEQSVEQVKRDLKAYLEESFKQLKSQNHLEIKVLNEAEGWLG----DPTNHAY 802

  Fly   325 LAVKAAIDEL--GLKVHPIVCPGATDSRFIREKGT-------------PAIGFSPIINTTMRIHD 374
            ..:|   ||:  ...|.|::         :||.|:             ||:.. |...:|...|.
Yeast   803 QILK---DEITTAWDVEPLL---------VREGGSISCLRMLERIFDAPAVQI-PCGQSTDNGHL 854

  Fly   375 HDEFLQADVYLNGIDVYKKIIRNL 398
            .:|.|:...:.|..::..|:...|
Yeast   855 ANENLRIKNWSNLTEILSKVFNRL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6733	NP_651123.1	Ac-peptdase-euk	1..401	CDD:273850	101/479 (21%)
CG6733	NP_651123.1	M20_AcylaseI_like	8..399	CDD:193524	101/479 (21%)
DUG2	NP_009840.3	WD40	19..336	CDD:421866
		WD40 repeat	23..60	CDD:293791
		WD40 repeat	74..121	CDD:293791
		WD40 repeat	126..158	CDD:293791
		WD40 repeat	166..213	CDD:293791
		WD40 repeat	226..280	CDD:293791
		WD40 repeat	288..324	CDD:293791
		WD40 repeat	343..372	CDD:293791
		M20_dipept_like_DUG2_type	437..878	CDD:349926	96/473 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810