DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6733 and CNDP1

DIOPT Version :9

Sequence 1:	NP_651123.1	Gene:	CG6733 / 42731	FlyBaseID:	FBgn0039052	Length:	401	Species:	Drosophila melanogaster
Sequence 2:	NP_116038.4	Gene:	CNDP1 / 84735	HGNCID:	20675	Length:	507	Species:	Homo sapiens

Alignment Length:	511	Identity:	100/511 - (19%)
Similarity:	182/511 - (35%)	Gaps:	171/511 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKW-----ENNEEIKIFR-EYLRIPTVHPDVDYTACVEFLKRQASSLNL-PVEVVYPAVQTKPV- 60
            ::|     ::.:.:..|| |..|:..|..|.     ::.|..:.:|::: |.::  |..|:.|:
Human    54 KEWVAIESDSVQPVPRFRQELFRMMAVAADT-----LQRLGARVASVDMGPQQL--PDGQSLPIP 111

  Fly    61 -VIIKWEGSQPELSSIVLNSHTDVVPVFR-EKWTHEPF-SADIDEEGRIFARGTQDMKSVGTQYL 122
             ||:...||.|...::....|.||.|..| :.|..:|: ..::|  |:::.||..|.|.....::
Human   112 PVILAELGSDPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVD--GKLYGRGATDNKGPVLAWI 174

  Fly   123 GAIRLLKASGFKPKRNLYVT---FVPDEETGGHLGMAEFVK---------TDY------------ 163
            .|:...:|.    :::|.|.   .:...|..|.:.:.|.|:         .||
Human   175 NAVSAFRAL----EQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQR 235

  Fly   164 -----YKKMNAGFSLDEGATSESDVHHLFYAERLRWGLKLKVSGTSG------------------ 205
                 |......:.:.|....:.|.|                |||.|
Human   236 KPAITYGTRGNSYFMVEVKCRDQDFH----------------SGTFGGILHEPMADLVALLGSLV 284

  Fly   206 --HGSLLLP--------------NTAGVKLNYLVNKLTEFR-TSQVENLARDSSLSKGDV----- 248
              .|.:|:|              ||  .|..:|  .|.|:| :|:||....|   :|.::
Human   285 DSSGHILVPGIYDEVVPLTEEEINT--YKAIHL--DLEEYRNSSRVEKFLFD---TKEEILMHLW 342

  Fly   249 --TTVNLTQLSGGVQ----SNVVPPLFEAVFDIRIAITVNVVAFEKQIRDWCEEAGGGIEIDFFQ 307
              .::::..:.|...    ..|:|......|.||:...:||.|.|||:....|        |.|.
Human   343 RYPSLSIHGIEGAFDEPGTKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLE--------DVFS 399

  Fly   308 K---------------EPYIGPTKLDNSNPYWLAVKAAIDELGLKVHPIVCPGATDSRFIREKGT 357
            |               .|:|  ..:|::.  :||.|.||..:          ..|:...||:..|
Human   400 KRNSSNKMVVSMTLGLHPWI--ANIDDTQ--YLAAKRAIRTV----------FGTEPDMIRDGST 450

  Fly   358 PAIG--FSPIINTTMRI----------HDHDEFLQADVYLNGIDVYKKIIRNLAEV 401
            ..|.  |..|::.::.:          |..:|.:....|:.|..::......:|::
Human   451 IPIAKMFQEIVHKSVVLIPLGAVDDGEHSQNEKINRWNYIEGTKLFAAFFLEMAQL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6733	NP_651123.1	Ac-peptdase-euk	1..401	CDD:273850	100/509 (20%)
CG6733	NP_651123.1	M20_AcylaseI_like	8..399	CDD:193524	98/498 (20%)
CNDP1	NP_116038.4	PRK08201	34..506	CDD:169276	100/509 (20%)
CNDP1	NP_116038.4	M20_dipept_like_CNDP	38..506	CDD:193551	100/509 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810