DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17111 and cutl-28

DIOPT Version :9

Sequence 1:	NP_651119.2	Gene:	CG17111 / 42727	FlyBaseID:	FBgn0039048	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_499971.2	Gene:	cutl-28 / 176895	WormBaseID:	WBGene00018256	Length:	696	Species:	Caenorhabditis elegans

Alignment Length:	751	Identity:	152/751 - (20%)
Similarity:	263/751 - (35%)	Gaps:	178/751 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 CWRICNEDPDCIAYVHLLDTD-----------ECHGYSYFERTSRYLAISGELP-LVADGEAVFY 139
            |.|.|:..|:|   .|...::           .||.:|             :.| |...|.....
Worm    51 CTRFCSSVPNC---THFTFSNAEPIEKKNGGFNCHLHS-------------KSPVLTTSGSRTVG 99

  Fly   140 EKTCLRVPDACRGRLWALTKIPGSTLVYHS--KKTISTLVTRRECAERCFFETQFRCLSASFAPS 202
            .||||.  :.|..|.:|..|.||.:||..|  .||.|  ::..||..:|..|:..|.       :
Worm   100 TKTCLE--NKCLKRSFAFEKFPGRSLVNSSFIIKTFS--ISMEECLSQCQKESSCRA-------A 153

  Fly   203 YRNNRERFRGEAGPGQRPSPRLGRCMLS--DRDKTVQPDAFRAAPYDEEYMENQCHERAIESDNC 265
            ..||....                |.||  ..:....|..:..|.|..:..||.|.:.|:.|..|
Worm   154 LHNNDTSL----------------CQLSRVSLNSVYNPRLYFKASYSVDLYENNCVDYAMTSSAC 202

  Fly   266 SYELYANSSFIYAEARYL----GLSQKECQAMCSHEAKF--YCQGVSFYYVNQLSLSECLLHSED 324
            :: :..|...:.:.:..|    | |..||:.||...::.  .|:  |:.|.|  |.:||.|....
Worm   203 TF-MRVNGGGLKSVSDQLIQNVG-SFDECEQMCVIRSRISDVCR--SYTYDN--STNECNLMWAS 261

  Fly   325 IVSLGPRSLK-LRENSVYMRRVKCLDVRVFCTRDEMTIKYNPKDWFVGKIYASMHSK-DCLARGS 387
            ...||...|: ::.|..:.....|::..:.|..|.:.:|.:....|:||:......| .|.....
Worm   262 ARMLGRSPLESMKPNLFHGDLDDCVNFSLKCREDNLEVKASSMRMFIGKMMTKKSKKIMCQEDYE 326

  Fly   388 GNGSVLLTLQIGSEVKENRCGILRAYEMTQEYQRTFISALVVIQNNPNVQTQGDRLIKVGCIQSN 452
            ||      ....|:....:||:    :..:....|:...:.|.:.:.::.|..|::::|.|....
Worm   327 GN------YDFSSKFDFKKCGL----DPNKSKDSTYRGMVHVKEGSTSLVTIRDKVLQVNCRLHK 381

  Fly   453 ATTS----LGVSVRDSSVDSSEPVPSAIALESSLEYTEHMFPHEGVVHYNSSTGP--HPHPSISL 511
            :..|    |.|.:.....:.:..|.|.:.:                     .|.|  ..:|..||
Worm   382 SMPSEEQFLSVQMNVRENNKTNQVMSDVVV---------------------VTAPPAQTNPKFSL 425

  Fly   512 QILDLSHQHETNDVQIGQNLELQIVAEYSPQQLAEHMELQLAPLPDFRATSLVAKTADNENFVLL 576
            :||.|. ..|.:.|.||....:.:..:.|.:              ||..|:||||.......:.:
Worm   426 KILGLD-STEADTVHIGDYGWIMLAVKNSAE--------------DFTVTNLVAKDVQTGRVLRI 475

  Fly   577 IDERGCPTDASVFPALERVHTASRSMLRARFHAFKFSGTANVSFDVKIRFCVERCSPSNC----- 636
            |||.||.....:...:.:  |.:...|:..|..|:  ....|.:...:..|...|.| .|
Worm   476 IDEDGCVLRRDIVKEIRK--TDNYVKLKISFSGFR--RQTEVVYHAMMETCTVGCMP-KCNQDMM 535

  Fly   637 ------------ISSSWQRRRRQADQPDRRPEDLRVQNPVY------ISTVVDVAPQPDNFTRSQ 683
                        :|....|.|.........|.:|::.:.||      ::.:...:|:..:|...:
Worm   536 LPEEETNVHSLPLSLDLPRHRMVRRSLAGEPRELQLTSDVYKVTGHKLTLLNPPSPKQFDFPAPK 600

  Fly   684 EELPLNYNIRVHGPDQSNTNSYLYGERGVLLIAGIDDPLHLDNV------CINQSLLIALFIFWL 742
            .:...|.|...|             |..|:::.      |..|:      |:...:...|.:...
Worm   601 SDFEFNDNGEFH-------------EGDVIVVK------HSPNLWTSVKHCLIDDVTCMLTVVLG 646

  Fly   743 ICQVALLFGCGMVLQRYRRLAKLEDERRRLHEEYLE 778
            ..|:.|:|.|.:::..|.:..:...|..|..|..::
Worm   647 AIQMFLMFSCFLIMYCYYQQWRFYRELNRPQEHNVQ 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17111	NP_651119.2	PAN_1	159..255	CDD:278453	24/99 (24%)
CG17111	NP_651119.2	PAN_AP_HGF	270..344	CDD:238532	20/80 (25%)
cutl-28	NP_499971.2	APPLE	30..103	CDD:128519	13/67 (19%)
		PAN_1	114..192	CDD:278453	25/102 (25%)
		PAN_1	202..292	CDD:278453	22/95 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JEZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12391
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.820