DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17119 and Ctns

DIOPT Version :9

Sequence 1:	NP_651116.1	Gene:	CG17119 / 42723	FlyBaseID:	FBgn0039045	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_011247627.1	Gene:	Ctns / 83429	MGIID:	1932872	Length:	409	Species:	Mus musculus

Alignment Length:	411	Identity:	168/411 - (40%)
Similarity:	236/411 - (57%)	Gaps:	45/411 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 THRLTTLLLLLLATVALGNAQSSQLTVDSHDITVLLNSNETFLVFANGLLDSDVEVALGTDSEDH 69
            |.|...||:|.|..:         :.::.::.||.|.:..| :...|| ..::|::.||......
Mouse     9 TMRRNWLLILTLFLL---------MFIEKYESTVSLTAPPT-VKLENG-SSTNVDITLGHPLNST 62

  Fly    70 LLLD---------------PATFVYPAGSTRNQSVVITGLKAGNVKVVADSDDANKEIVKDVFVR 119
            |::.               |...:.|.|. :|.|..:|....|.|.|....:.:|:...:   :|
Mouse    63 LVITFEVTFRSKNLTIVELPDEVIVPRGE-KNASFQVTSQNIGQVTVFLHGNHSNQTCPR---IR 123

  Fly   120 VTVAKSRALIYTSIIFGWVYFVAWSVSFYPQIWSNYRRKSVEGLNFDFLALNIVGFTLYSMFNCG 184
            ..|..||.:...:.:.||:||:|||||||||:..|:|||||.||:|||||||:.||..||:||.|
Mouse   124 FLVIHSRIVSIINQVIGWIYFMAWSVSFYPQVIQNWRRKSVIGLSFDFLALNLTGFVAYSVFNIG 188

  Fly   185 LYFIEDLQNEYEVRYPLGVNPVMLNDVVFSLHAMFATCITILQCFFYQRAQQRVSFIAYGILAIF 249
            |.::..:|.|:.::||.|||||..||..|||||:..|.|.||||..|:|..||||:.:.|.|.:.
Mouse   189 LLWVPYIQEEFLLKYPNGVNPVDSNDAFFSLHAVALTLIVILQCCLYERGNQRVSWPSIGFLVLA 253

  Fly   250 AVVVVVSAGLAGGSVIHWLDFLYYCSYVKLTITIIKYVPQALMNYRRKSTSGWSIGNILLDFTGG 314
            .:.|:|:..:|...:..||.||:..||:||.||:|||.|||.||:..|||.|||||.:|||||||
Mouse   254 WLFVLVTMIVAAVGITTWLQFLFCFSYIKLIITLIKYFPQAYMNFYYKSTKGWSIGGVLLDFTGG 318

  Fly   315 TLSMLQMILNAHNYDDWVSIFGDPTKFGLGLFSVLFDVFFMLQHYVFYR--------------HS 365
            :.|:|||.|.::|.|.|..|||||||||||:|::.|||.|.:||:..||              |.
Mouse   319 SFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFTIFFDVVFFIQHFYLYRKKPGLQAAHTGPDSHP 383

  Fly   366 RESSSSDLTTVTDVQNRTNES 386
            .::.:|.|..:|..|: ||.|
Mouse   384 SQNWASCLQLMTLPQS-TNIS 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17119	NP_651116.1	2A43	129..362	CDD:130026	128/232 (55%)
		PQ-loop	132..187	CDD:282099	36/54 (67%)
		PQ-loop	272..324	CDD:282099	33/51 (65%)
Ctns	XP_011247627.1	2A43	134..366	CDD:130026	128/231 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847759
Domainoid	1	1.000	72	1.000	Domainoid score	I9321
eggNOG	1	0.900	-	-		E1_KOG3145
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3625
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2763
Isobase	1	0.950	-	0	Normalized mean entropy	S2170
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1138417at2759
OrthoFinder	1	1.000	-	-		FOG0002383
OrthoInspector	1	1.000	-	-		oto95013
orthoMCL	1	0.900	-	-		OOG6_102383
Panther	1	1.100	-	-	LDO	PTHR13131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2105
SonicParanoid	1	1.000	-	-		X382
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740