Protein Alignment Ctns and CTNS

DIOPT Version :10

• Sequence 1: NP_651116.1
• Gene: Ctns / 42723
• FlyBaseID: FBgn0039045
• Length: 397
• Species: Drosophila melanogaster
• Sequence 2: NP_001026851.2
• Gene: CTNS / 1497
• HGNCID: 2518
• Length: 400
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 162/379 - (42%)
• Similarity: 223/379 - (58%)
• Gaps: 52/379 - (13%)

  Fly     4 STHRLTTLLLLLLATVALGNAQSSQLTVDSHDITVLLNSNETFLVFANGLLDSDVEVALGTDSED 68
            ||:...||...|.||:.:    :.::|..|.:||:|                   |:
Human    39 STNVSLTLRPPLNATLVI----TFEITFRSKNITIL-------------------EL-------- 72

  Fly    69 HLLLDPATFVYPAGSTRNQSVVITGLKAGNVKVVADSDDANKEIVKDVFVRVTVAKSRALIYTSI 133
                 |...|.|.|.| |.|..:|....|.:.|....:.:|:...:   :|..|.:|.|:...:.
Human    73 -----PDEVVVPPGVT-NSSFQVTSQNVGQLTVYLHGNHSNQTGPR---IRFLVIRSSAISIINQ 128

  Fly   134 IFGWVYFVAWSVSFYPQIWSNYRRKSVEGLNFDFLALNIVGFTLYSMFNCGLYFIEDLQNEYEVR 198
            :.||:||||||:|||||:..|:|||||.||:|||:|||:.||..||:||.||.::..::.::.::
Human   129 VIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLK 193

  Fly   199 YPLGVNPVMLNDVVFSLHAMFATCITILQCFFYQRAQQRVSFIAYGILA---IFAVVVVVSAGLA 260
            ||.|||||..|||.|||||:..|.|.|:||..|:|..||||:.|.|.|.   :||.|.::.|.:
Human   194 YPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAV- 257

  Fly   261 GGSVIHWLDFLYYCSYVKLTITIIKYVPQALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNA 325
              .|..||.||:..||:||.:|::||.|||.||:..|||.||||||:|||||||:.|:|||.|.:
Human   258 --GVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQS 320

  Fly   326 HNYDDWVSIFGDPTKFGLGLFSVLFDVFFMLQHYVFYRH------SRESSSSDL 373
            :|.|.|..|||||||||||:||::|||.|.:||:..||.      :|..|.|.|
Human   321 YNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGLQAARTGSGSRL 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ctns	NP_651116.1	2A43	129..362	CDD:130026	128/235 (54%)
CTNS	NP_001026851.2	2A43	125..357	CDD:130026	128/234 (55%)