Protein Alignment CG17121 and Hsd17b12

DIOPT Version :10

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_114455.2
• Gene: Hsd17b12 / 84013
• RGDID: 708367
• Length: 312
• Species: Rattus norvegicus
• Alignment Length: 282
• Identity: 69/282 - (24%)
• Similarity: 130/282 - (46%)
• Gaps: 41/282 - (14%)

  Fly    92 GKVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAYK---NDVSS 153
            |:.|:||||..|:|:....|||:||.|:.::.       .:.:.|.::...:.:.:.   ..::.
  Rat    50 GEWAVVTGGTDGIGKSYAEELAKRGMKIVLIS-------RSQDKLKEVSNNIKEKFNVETRTIAV 107

  Fly   154 PRELQLMAAKVEKELGPVDI--LVNNASL---MP--MTSTPSLKSDEIDTILQLNLGSYIMTTKE 211
            ...|..:..|::..|..::|  ||||..:   .|  ....|.| .:.|..::.:|:.|....|:.
  Rat   108 DFSLDDIYDKIKTGLSGLEIGVLVNNVGMSYEYPEYFLEIPDL-DNTIKKLININVLSICKVTRL 171

  Fly   212 FLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAELRLSDCDYVRTTVANAY 276
            .||.|:.|..|.::.:::.:|::|:|...:|:|||..::.|.:.|..|.: |...:|::.
  Rat   172 VLPGMVERSKGVILNISSASGMLPVPLLTVYSATKAFVDFFSQCLHEEYK-SKGIFVQSV----- 230

  Fly   277 LMRTSGDLPLLSDAGIAK-SYPGLPTPYVAEKIVKGVL----LNERMV-YVPKIFALSVWLLRLL 335
                   ||......:|| ..|.|..| .||..||..:    |..|.. ||  |.|:...:..:|
  Rat   231 -------LPFFVATKLAKIRKPTLDKP-SAETFVKSAIKTVGLQTRTTGYV--IHAIMGSINSIL 285

  Fly   336 PTKWQDYMLLRFYHFDVRSSHL 357
            | :|..:..:..::..:|:.:|
  Rat   286 P-RWIYFKTIMGFNKSLRNRYL 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	Rossmann-fold NAD(P)(+)-binding proteins	94..338	CDD:473865	65/259 (25%)
Hsd17b12	NP_114455.2	17beta-HSD1_like_SDR_c	50..289	CDD:187614	66/263 (25%)
		Di-lysine motif. /evidence=ECO:0000250	308..312