DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17121 and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_651114.1	Gene:	CG17121 / 42721	FlyBaseID:	FBgn0039043	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	338	Identity:	91/338 - (26%)
Similarity:	132/338 - (39%)	Gaps:	66/338 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TAVPAGAVTVTGPTASATPTATQAAAQAHRNDETTRAIFNLKVIVFLLLLPLVLLAVFLKHLLDY 79
            |.:|..|.:|  |..||.|         ||         .:||     ||...|.|:|..:..|.
Human    28 TGMPVPATSV--PCPSAGP---------HR---------TMKV-----LLLTGLGALFFAYYWDD 67

  Fly    80 LFALGLKEKDVSGKVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRCVA 144
            .|    ....:.|...|:||..:|:|.|:....||.|..|.:.       ..|..||.|:   |.
Human    68 NF----DPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLT-------AHTEALLQKV---VG 118

  Fly   145 KAYK----------NDVSSPRELQLMAAKVEKELGPVDILVNNASLMPMTSTPSLKSDEIDTILQ 199
            ...|          .|::||...:.:......:||.:|.||.|........|.:........::|
Human   119 NCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQ 183

  Fly   200 LNLGSYIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAELRLSD 264
            :|..||:..|...||.:.:.| |.||.|::|.|.||...:..|:|.|:.::||..|||.||.:.|
Human   184 VNFVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQD 247

  Fly   265 CDYVRTTVANAYLMRTSGDLPLLSDAGIAKSYPGL------PTPYVAEKIVKGVLLNERMVYVPK 323
            .:...|...          |.|...|..|::..|:      |.|..|..:::|.......|:.|.
Human   248 VNVAITMCV----------LGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYPW 302

  Fly   324 IFALSVWLLRLLP 336
            .|.|...|.|.||
Human   303 RFRLLCLLRRWLP 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	DltE	91..349	CDD:223377	72/262 (27%)
CG17121	NP_651114.1	NADB_Rossmann	94..338	CDD:304358	71/259 (27%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	65/248 (26%)
		PRK08251	78..302	CDD:181324	64/244 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3540
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860